Drug Transporters and Metabolizing Enzymes in Antimicrobial Drug Pharmacokinetics: Mechanisms, Drug-Drug Interactions, and Clinical Implications

被引：0

作者：

Lin, Kaili ^{[1
]}

Wang, Ruoqing ^{[1
]}

Li, Tong ^{[1
]}

Zuo, Yawen ^{[1
]}

Yang, Shilei ^{[1
]}

Dong, Deshi ^{[1
]}

Zhu, Yanna ^{[1
]}

机构：

[1] Dalian Med Univ, Affiliated Hosp 1, Dept Pharm, Dalian 116011, Peoples R China

来源：

BIOMOLECULES | 2025年 / 15卷 / 06期

基金：

中国国家自然科学基金;

关键词：

antimicrobial drugs; drug transporters; metabolizing enzymes; pharmacokinetics; drug-drug interactions; COA REDUCTASE INHIBITORS; IN-VIVO EVIDENCE; ORGANIC ANION; PEPTIDE TRANSPORTERS; P-GLYCOPROTEIN; HEPATIC-UPTAKE; MEDIATED TRANSPORT; VITRO; DISPOSITION; ANTIBIOTICS;

D O I：

10.3390/biom15060864

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drug transporters and metabolizing enzymes are integral components of drug disposition, governing the absorption, distribution, metabolism, and excretion (ADME) of pharmaceuticals. Their activities critically determine therapeutic efficacy and toxicity profiles, particularly for antimicrobial agents, one of the most widely prescribed drug classes frequently co-administered with other medications. Emerging evidence highlights the clinical significance of the drug-drug interactions (DDIs) mediated by these systems, which may alter antimicrobial pharmacokinetics, compromise treatment outcomes, or precipitate adverse events. With the continuous introduction of novel antimicrobial agents into clinical practice, the role of drug transporters and metabolizing enzymes in the pharmacokinetics of antibiotics and the DDIs between antibiotics and other drugs mediated by these transporters and enzymes are important to determine in order to provide a theoretical basis for the safe and effective use of antimicrobial drugs in clinical use.

引用

页数：17