Vitamin C Deficiency Megaloblastic Anemia Mimicking Hemolytic Anemia: A Case Report

被引:0
作者
Sano, Kaito [1 ]
Imoto, Naoto [2 ]
Koketsu, Haruki [2 ]
Kubo, Atsushi [2 ]
Ito, Rie [2 ]
Nakashima, Marie [2 ]
Kurahashi, Shingo [2 ]
机构
[1] Toyohashi Municipal Hosp, Dept Gen Internal Med, Toyohashi, Japan
[2] Toyohashi Municipal Hosp, Dept Hematol & Oncol, Toyohashi, Japan
关键词
scurvy; thrombotic thrombocytopenic purpura; megaloblastic anemia; vitamin C deficiency; hyper-segmented neutrophil; THROMBOTIC MICROANGIOPATHIES; SCURVY;
D O I
10.2169/internalmedicine.5013-24
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 31-year-old female presented at our hospital with fatigue and subcutaneous bleeding. Blood tests revealed hemolytic anemia. The patient had Coombs-negative normocytic anemia and thrombocytopenia; therefore, thrombotic thrombocytopenic purpura was ruled out. On day two, we noticed that the eating habits of the patient, hypersegmented neutrophils, and megaloblastic changes suggested malnutrition; therefore, we initiated vitamin supplementation. On day six, the vitamin C levels were <0.2 mu g/mL, and the patient was therefore diagnosed with scurvy. Scurvy can mimic hemolytic anemia by causing normocytic megaloblastic anemia with a high reticulocyte count. Hypersegmented neutrophils and a detailed medical history are important for making a differential diagnosis.
引用
收藏
页数:6
相关论文
共 26 条
[1]   Behind the Skin: A Rare Case of Scurvy-Associated Megaloblastic Anemia [J].
Alhatem, Albert ;
Cai, Donghong .
CLINICAL MEDICINE INSIGHTS-CASE REPORTS, 2019, 12
[2]   Current hematological findings in cobalamin deficiency.: A study of 201 consecutive patients with documented cobalamin deficiency [J].
Andrès, E ;
Affenberger, S ;
Zimmer, J ;
Vinzio, S ;
Grosu, D ;
Pistol, G ;
Maloisel, F ;
Weitten, T ;
Kaltenbach, G ;
Blicklé, JF .
CLINICAL AND LABORATORY HAEMATOLOGY, 2006, 28 (01) :50-56
[3]   SCORBUTIC MEGALOBLASTIC ANAEMIA RESPONDING TO ASCORBIC ACID ALONE [J].
ASQUITH, P ;
OELBAUM, MH ;
DAWSON, DW .
BRITISH MEDICAL JOURNAL, 1967, 4 (5576) :402-&
[4]  
Bailey L. B., 2012, Present knowledge in nutrition, P321
[5]   Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study [J].
Bendapudi, Pavan K. ;
Hurwitz, Shelley ;
Fry, Ashley ;
Marques, Marisa B. ;
Waldo, Stephen W. ;
Li, Ang ;
Sun, Lova ;
Upadhyay, Vivek ;
Hamdan, Ayad ;
Brunner, Andrew M. ;
Gansner, John M. ;
Viswanathan, Srinivas ;
Kaufman, Richard M. ;
Uhl, Lynne ;
Stowell, Christopher P. ;
Dzik, Walter H. ;
Makar, Robert S. .
LANCET HAEMATOLOGY, 2017, 4 (04) :E157-E164
[6]   Case 22-2018: A 64-Year-Old Man with Progressive Leg Weakness, Recurrent Falls, and Anemia [J].
Bennett, Susan E. ;
Schmitt, William P. ;
Stanford, Fatima C. ;
Baron, Jason M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (03) :282-289
[7]   Diagnosis and management of thrombotic thrombocytopenic purpura (TTP) in Australia: findings from the first 5 years of the Australian TTP/thrombotic microangiopathy registry [J].
Blombery, P. ;
Kivivali, L. ;
Pepperell, D. ;
McQuilten, Z. ;
Engelbrecht, S. ;
Polizzotto, M. N. ;
Phillips, L. E. ;
Wood, E. ;
Cohney, S. .
INTERNAL MEDICINE JOURNAL, 2016, 46 (01) :71-79
[8]  
Cohen S A, 2001, J Am Board Fam Pract, V14, P314
[9]   Adult Vitamin B12 Deficiency-Associated PseudoThrombotic Microangiopathy: A Systematic Review of Case Reports [J].
Ganipisetti, Venu M. ;
Maringanti, Babu Sriram ;
Lingas, Elvina C. ;
Naha, Kushal .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (03)
[10]   Reticulocyte count: a simple test but tricky interpretation! [J].
Gaur, Malvika ;
Sehgal, Tushar .
PAN AFRICAN MEDICAL JOURNAL, 2021, 40