The Role of the Extracellular Matrix in Inducing Cardiac Cell Regeneration and Differentiation

被引：0

作者：

Romano, Nicla ^{[1
]}

机构：

[1] Link Campus Univ, Dept Life Sci Hlth & Hlth Profess, I-00165 Rome, Italy

来源：

CELLS | 2025年 / 14卷 / 12期

关键词：

zebrafish; heart; extracellular matrix; FOCAL ADHESION KINASE; ZEBRAFISH HEART REGENERATION; GROWTH-FACTOR; CARDIOVASCULAR-DISEASE; INTERCALATED DISC; CARDIOMYOCYTE PROLIFERATION; MYOCARDIAL-INFARCTION; MYOCYTE INTERACTION; EPICARDIAL CELLS; BASIC MECHANISMS;

D O I：

10.3390/cells14120875

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The adult human heart has a limited ability to regenerate after injury, leading to the formation of fibrotic scars and a subsequent loss of function. In fish, mice, and humans, cardiac remodeling after myocardial injury involves the activation of epicardial and endocardial cells, pericytes, stem cells, and fibroblasts. The heart's extracellular matrix (ECM) plays a significant role in the regeneration and recovery process. The epicardium, endocardium, and pericytes reactivate the embryonic program in response to ECM stimulation, which leads to epithelial-mesenchymal transition, cell migration, and differentiation. This review analyzes the role of ECM in guiding the differentiation or dedifferentiation and proliferation of heart components by comparing significant findings in a zebrafish model with those of mammals.

引用

页数：22

共 196 条

[1] The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity [J].

Alam, Samer G. ;

Zhang, Qiao ;

Prasad, Nripesh ;

Li, Yuan ;

Chamala, Srikar ;

Kuchibhotla, Ram ;

Birendra, K. C. ;

Aggarwal, Varun ;

Shrestha, Shristi ;

Jones, Angela L. ;

Levy, Shawn E. ;

Roux, Kyle J. ;

Nickerson, Jeffrey A. ;

Lele, Tanmay P. .

SCIENTIFIC REPORTS, 2016, 6

[2] Multiple defects in type III collagen synthesis are associated with the pathogenesis of abdominal aortic aneurysms [J].

Anderson, DW ;

Edwards, TK ;

Ricketts, MH ;

Kuivaniemi, H ;

Tromp, G ;

Stolle, CA ;

Deak, SB ;

Boyd, CD .

ABDOMINAL AORTIC ANEURYSM: GENETICS, PATHOPHYSIOLOGY, AND MOLECULAR BIOLOGY, 1996, 800 :216-228

[3] Zebrafish as a Versatile Model for Cardiovascular Research: Peering into the Heart of the Matter [J].

Angom, Ramcharan Singh ;

Singh, Meghna ;

Muhammad, Huzaifa ;

Varanasi, Sai Manasa ;

Mukhopadhyay, Debabrata .

CELLS, 2025, 14 (07)

[4] Environmental pollution and toxic substances: Cellular apoptosis as a key parameter in a sensible model like fish [J].

AnvariFar, Hossein ;

Amirkolaie, A. K. ;

Jalali, Ali M. ;

Miandare, H. K. ;

Sayed, Alaa H. ;

Ucuncu, Sema Isisag ;

Ouraji, Hossein ;

Ceci, Marcello ;

Romano, Nicla .

AQUATIC TOXICOLOGY, 2018, 204 :144-159

[5] Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages [J].

Asgarpour, Kasra ;

Shojaei, Zahra ;

Amiri, Fatemeh ;

Ai, Jafar ;

Mahjoubin-Tehran, Maryam ;

Ghasemi, Faezeh ;

ArefNezhad, Reza ;

Hamblin, Michael R. ;

Mirzaei, Hamed .

CELL COMMUNICATION AND SIGNALING, 2020, 18 (01)

[6] Zebrafish as a model to study cardiac development and human cardiac disease [J].

Bakkers, Jeroen .

CARDIOVASCULAR RESEARCH, 2011, 91 (02) :279-288

[7] Cardiac stem cells: Isolation, expansion and experimental use for myocardial regeneration [J].

Barile L. ;

Chimenti I. ;

Gaetani R. ;

Forte E. ;

Miraldi F. ;

Frati G. ;

Messina E. ;

Giacomello A. .

Nature Clinical Practice Cardiovascular Medicine, 2007, 4 (Suppl 1) :S9-S14

[8] Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction [J].

Barile, Lucio ;

Lionetti, Vincenzo ;

Cervio, Elisabetta ;

Matteucci, Marco ;

Gherghiceanu, Mihaela ;

Popescu, Laurentiu M. ;

Torre, Tiziano ;

Siclari, Francesco ;

Moccetti, Tiziano ;

Vassalli, Giuseppe .

CARDIOVASCULAR RESEARCH, 2014, 103 (04) :530-541

[9] Human Adipose-Derived Stem Cell-Conditioned Medium Promotes Vascularization of Nanostructured Scaffold Transplanted into Nude Mice [J].

Barone, Ludovica ;

Rossi, Federica ;

Valdatta, Luigi ;

Cherubino, Mario ;

Papait, Roberto ;

Binelli, Giorgio ;

Romano, Nicla ;

Bernardini, Giovanni ;

Gornati, Rosalba .

NANOMATERIALS, 2022, 12 (09)

[10]

Barron M, 2000, DEV DYNAM, V218, P383, DOI 10.1002/(SICI)1097-0177(200006)218:2<383::AID-DVDY11>3.0.CO

← 1 2 3 4 5 6 7 8 9 10 →