Research progress on estrogen receptor-positive/progesterone receptor-negative breast cancer

被引：1

作者：

Lu, Zhengjia ^{[1
]}

Wang, Tingrui ^{[1
]}

Wang, Lu ^{[1
]}

Ming, Jia ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 2, Chongqing, Peoples R China

来源：

TRANSLATIONAL ONCOLOGY | 2025年 / 56卷

关键词：

Breast cancer; Estrogen receptor; Progesterone receptor; Endocrine therapy; PATIENT-LEVEL METAANALYSIS; PROGESTERONE-RECEPTOR; STEROID-RECEPTOR; GENE-EXPRESSION; POSTMENOPAUSAL PATIENTS; PROTEIN EXPRESSION; ENDOCRINE THERAPY; DOWN-REGULATION; MAMMARY-GLAND; RISK-FACTORS;

D O I：

10.1016/j.tranon.2025.102387

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer, which arises from the epithelial tissue of the breast, is one of the most common cancers affecting women worldwide. Its incidence and mortality rates have been increasing in both developed and developing countries. As a hormone-dependent cancer, breast cancer is classified into several molecular subtypes based on the expression of key markers: Estrogen Receptor (ER), Progesterone Receptor (PR), Human Epidermal Growth Factor Receptor 2 (HER-2), and Ki67. PR loss is associated with endocrine resistance and a poorer prognosis in breast cancer. Despite this, the underlying mechanisms of ER-positive/PR-negative (ER+PR-) breast cancer remain poorly understood. This study aims to review recent advancements in research on ER+PR- breast cancer, analyze its clinical characteristics and molecular mechanisms, and provide recommendations for more targeted therapeutic approaches.

引用

页数：14

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