Recommendations for diagnosis, treatment and follow-up of patients with uveal melanoma

Uveal melanoma is the most common primary malignant intraocular tumor in adults. Uveal melanomas include choroidal melanoma (90%), ciliary body melanoma (6%), and iris melanoma (4%). Between 2017 and 2021, an average of 23 people were diagnosed with uveal melanoma annually in Slovenia, representing 3.7% of all melanomas. The first comprehensive and multidisciplinary treatment guidelines in Slovenia cover choroidal and ciliary body melanomas and are based on the American NCCN guidelines. These recommendations provide a holistic overview of risk factors, clinical presentation, and local treatment options for this cancer, as well as modern approa-ches to the multidisciplinary management of distant metastases- including the possibility of full blood genotyping for the presence of the human leukocyte antigen (HLA)-A02:01. The aim of these guidelines is to support specialists from various fields in both communicating with patients and their families, and in choosing the most appropriate treatment options.