Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes : Randomized, double-blind, placebo-controlled trial

被引：0

作者：

Li, Yingsha ^{[1
]}

Wang, Qianran ^{[1
]}

Liu, Yi ^{[1
]}

Li, Qiang ^{[1
]}

Xia, Weijie ^{[2
]}

Lin, Shaoyang ^{[1
]}

Yang, Qian ^{[3
]}

Scholze, Alexandra ^{[4
,5
]}

Zhao, Zhigang ^{[1
]}

He, Hongbo ^{[1
]}

Zhang, Hexuan ^{[1
]}

Yan, Zhencheng ^{[1
]}

Tepel, Martin ^{[6
,7
,8
]}

Mu, Huaming ^{[3
]}

Zhu, Zhiming ^{[1
]}

Liu, Daoyan ^{[1
]}

机构：

[1] Army Med Univ, Daping Hosp, Chongqing Inst Hypertens, Dept Hypertens & Endocrinol,Ctr Hypertens & Metab, Chongqing 400042, Peoples R China

[2] Army Med Univ, Daping Hosp, Res Inst Surg, Dept Plast & Cosmet Surg, Chongqing 400042, Peoples R China

[3] Chongqing Univ Three Gorges Hosp, Heart Ctr, Dept Cardiol, Chongqing 404100, Peoples R China

[4] Univ Southern Denmark, Dept Clin Res, Odense, Denmark

[5] Odense Univ Hosp, Dept Cardiothorac & Vasc Surg, DK-5000 Odense C, Denmark

[6] Odense Univ Hosp, Dept Nephrol, Odense, Denmark

[7] Univ Southern Denmark, Inst Mol Med Cardiovasc & Renal Res, Odense, Denmark

[8] Univ Southern Denmark, Inst Clin Res, DK-5000 Odense C, Denmark

来源：

ISCIENCE | 2025年 / 28卷 / 06期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

MEAN PLATELET VOLUME; SUPPLEMENTATION; OVERWEIGHT; ARTERY; PROTECTION; DISEASE; PLASMA; OBESE;

D O I：

10.1016/j.isci.2025.112719

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Peripheral arterial disease (PAD) significantly elevates the risk of cardiovascular events in patients with type 2 diabetes (T2D). The role of transient receptor potential canonical type 6 (TRPC6) channel mediated increased calcium entry have been identified on platelets from patients with T2D. It remains unknown whether taurine benefits vascular function in patients with T2D. Diabetic patients aged 60.0 +/- 8.6 years in the taurine group, N = 82; and 59.1 +/- 10.4 years in the placebo group, N = 83 were randomly enrolled and received either taurine (2.4 g/day) or placebo for 12 weeks. Compared to the placebo, taurine led to a significant reduction in systolic BP, and improvement of endothelium-dependent or-independent vasodilation and pulse wave velocity after taurine 12 weeks in patients with T2D. Taurine significantly inhibited the activation of platelet calcium influx in patients with T2D. Taurine may exert beneficial the effects on blood pressure and vascular dysfunction in patients with T2D.

引用

页数：12

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