Investigation of antimicrobial, antioxidant, and anticancer properties of novel chitosan-based nanocomposite materials reinforced with biosynthesized Ag nanoparticles

被引：0
作者：
Erol, Ibrahim [1 ,2 ]
Mutlu, Turan [1 ]
Hazman, Ömer [1 ,2 ]
Khamidov, Gofur [2 ]
机构：
[1] Afyon Kocatepe University, Faculty of Science and Arts, Department of Chemistry, Afyonkarahisar
[2] Samarkand State University, Faculty of Chemistry, Department of Organic and Bioorganic Chemistry, University blvd-15, Samarkand
来源：
Journal of Molecular Liquids | 2025年 / 420卷
关键词：
Anticancer; Antimicrobial properties; Chitosan; Methacrylate; Silver nanoparticle;
D O I：
10.1016/j.molliq.2025.126855
中图分类号：
学科分类号：
摘要：
Due to environmental and climatic problems caused by synthetic polymers, the need for biomaterials is increasing daily due to a cleaner environment and sustainability. This study produced new nanocomposites based on biopolymer chitosan (CS). Nanocomposites were prepared by combining a new methacrylate polymer, poly(2-{[(2,4-dichlorophenyl)methyl]amino}-2-oxoethyl-2-methylprop-2-enoate (PDCBMA), CS, and biosynthesized Ag NPs by hydrothermal method. NMR, FTIR, XRD, SEM, EDX and TEM were used to characterize the prepared materials. According to thermogravimetric analysis (TGA) data, adding Ag NPs increased the thermal stability and glass transition temperature (Tg) value of the PDCBMA-CS blend. The addition of 7 % Ag NPs decreased the contact angle value of CS from 90.71° to 67.10°, making the CS surface relatively hydrophilic. With 7 % Ag NP loading, the inhibition zone of CS against E. coli pathogen increased from 11.12 ± 1.05 mm to 14.09 ± 1.44 mm. The nanocomposite containing 5 % Ag NPs showed toxic effects on cancer (A549) cells at concentrations as low as 16 µg/mL, while it showed non-cytotoxic effects on healthy (L929) cells. The data suggest that PDCBMA-CS/Ag nanocomposites can be used as alternative materials in food, healthcare, and biomedical fields. © 2025 Elsevier B.V.
引用
收藏
相关论文
共 54 条
[31]  
Tayel A.A., Moussa S., El-Tras W.F., Knittel D., Opwis K., Schollmeyer E., Anticandidal action of fungal chitosan against Candida albicans, Int. J. Biol. Macromol., 47, pp. 454-457, (2010)
[32]  
Qin C., Li H., Xiao Q., Liu Y., Zhu J., Du Y., Water-solubility of chitosan and its antimicrobial activity, Carbohydr. Polym., 63, 3, pp. 367-374, (2006)
[33]  
Wang B., Li T., Guo W., Wang R., Li Y., Zhu X., Song P., He Y., Synthesis of Ag@chitosan/copolymer with dual-active centers for high antibacterial activity, Int. J. Biol. Macromol., 174, pp. 198-206, (2021)
[34]  
Maqbool Q., Kruszka D., Kachlicki P., Franklin G., Retracted Article: Organometallic Ag nanostructures prepared using Hypericum perforatum extract are highly effective against multidrug-resistant bacteria, RSC Adv., 8, 53, pp. 30562-30572, (2018)
[35]  
Abdellatif A.A.H., Alturki H.N.H., Tawfeek H.M., Different cellulosic polymers for synthesizing silver nanoparticles with antioxidant and antibacterial activities, Sci. Rep., 11, 1, (2021)
[36]  
Sivrier M., Hazman O., Tillayev S., Erol I., Novel Bionanocomposites Containing Green Synthesized Silver NPs of a Carboxymethyl Cellulose-Based Blend
[37]  
Thermal, Optical, Biological and Dielectric Properties, J. Polym. Environ., 31, 9, pp. 3857-3874, (2023)
[38]  
Cadinoiu A.N., Rata D.M., Daraba O.M., Ichim D.L., Popescu I., Solcan C., Solcan G., Silver Nanoparticles Biocomposite Films with Antimicrobial Activity: In Vitro and In Vivo Tests, Int. J. Mol. Sci., 23 18), (2022)
[39]  
Gao F., Mi Y., Wu X., Yao J., Qi Q., Chen W., Cao Z., Preparation of quaternized chitosan/Ag composite nanogels in inverse miniemulsions for durable and antimicrobial cotton fabrics, Carbohydr. Polym., 278, (2022)
[40]  
Ding L., Shan X., Zhao X., Zha H., Chen X., Wang J., Cai C., Wang X., Li G., Hao J., Yu G., Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata polysaccharide for wound healing applications, Carbohydr. Polym., 157, pp. 1538-1547, (2017)
123456