Investigation of antimicrobial, antioxidant, and anticancer properties of novel chitosan-based nanocomposite materials reinforced with biosynthesized Ag nanoparticles

被引：0
作者：
Erol, Ibrahim [1 ,2 ]
Mutlu, Turan [1 ]
Hazman, Ömer [1 ,2 ]
Khamidov, Gofur [2 ]
机构：
[1] Afyon Kocatepe University, Faculty of Science and Arts, Department of Chemistry, Afyonkarahisar
[2] Samarkand State University, Faculty of Chemistry, Department of Organic and Bioorganic Chemistry, University blvd-15, Samarkand
来源：
Journal of Molecular Liquids | 2025年 / 420卷
关键词：
Anticancer; Antimicrobial properties; Chitosan; Methacrylate; Silver nanoparticle;
D O I：
10.1016/j.molliq.2025.126855
中图分类号：
学科分类号：
摘要：
Due to environmental and climatic problems caused by synthetic polymers, the need for biomaterials is increasing daily due to a cleaner environment and sustainability. This study produced new nanocomposites based on biopolymer chitosan (CS). Nanocomposites were prepared by combining a new methacrylate polymer, poly(2-{[(2,4-dichlorophenyl)methyl]amino}-2-oxoethyl-2-methylprop-2-enoate (PDCBMA), CS, and biosynthesized Ag NPs by hydrothermal method. NMR, FTIR, XRD, SEM, EDX and TEM were used to characterize the prepared materials. According to thermogravimetric analysis (TGA) data, adding Ag NPs increased the thermal stability and glass transition temperature (Tg) value of the PDCBMA-CS blend. The addition of 7 % Ag NPs decreased the contact angle value of CS from 90.71° to 67.10°, making the CS surface relatively hydrophilic. With 7 % Ag NP loading, the inhibition zone of CS against E. coli pathogen increased from 11.12 ± 1.05 mm to 14.09 ± 1.44 mm. The nanocomposite containing 5 % Ag NPs showed toxic effects on cancer (A549) cells at concentrations as low as 16 µg/mL, while it showed non-cytotoxic effects on healthy (L929) cells. The data suggest that PDCBMA-CS/Ag nanocomposites can be used as alternative materials in food, healthcare, and biomedical fields. © 2025 Elsevier B.V.
引用
收藏
相关论文
共 54 条
[1]  
Alsalmah H.A., Rajeh A., Nur O., Optical, conductivity, dielectric, and magnetic properties of polymer nanocomposite based on PAM/cs matrix and ZnFe<sub>2</sub>O<sub>4</sub> NPs for use in magneto-electronic and energy storage capacitor devices, Ceram. Int., 50, 7, pp. 12167-12174, (2024)
[2]  
Alhussain H., Alghamdi A.M., Elamin N.Y., Et al., Recent Progress in Enhanced Optical, Mechanical, Thermal Properties, and Antibacterial Activity of the Chitosan/Polyvinylalcohol/Co<sub>3</sub>O<sub>4</sub>, Nanocomposites for Optoelectronics and Biological Applications, J Polym. Environ., 32, pp. 3735-3748, (2024)
[3]  
Alqarni L.S., Alghamdi A.M., Elamin N.Y., Rajeh A., Enhancing the optical, electrical, dielectric properties and antimicrobial activity of chitosan/gelatin incorporated with Co-doped ZnO nanoparticles: Nanocomposites for use in energy storage and food packaging, J. Mol. Struct., 1297, (2024)
[4]  
Zhang S., Ali M., Nawaz F., Et al., (2025)
[5]  
Hevira L., Ighalo J.O., Sondari D., Chitosan-based polysaccharides for effective synthetic dye adsorption, J. Mol. Liq., 393, (2024)
[6]  
Magdy G., Aboelkassim E., Abd Elhaleem S.M., Belal F., A comprehensive review on silver nanoparticles: Synthesis approaches, characterization techniques, and recent pharmaceutical, environmental, and antimicrobial applications, Microchem. J., 196, (2024)
[7]  
Erol I., Hazman O., Khamidov G., Savrik M., Improved physical, thermal, and biological properties of green synthesized Ag-containing nanocomposites of a novel chitosan-based blend, J. Mol. Liq., 392, 1, (2023)
[8]  
Abutalib M.M., Rajeh A., Enhanced structural, electrical, mechanical properties and antibacterial activity of Cs/PEO doped mixed nanoparticles (Ag/TiO<sub>2</sub>) for food packaging applications, Polym. Test., 93, (2021)
[9]  
Alghamdi H.M., Abutalib M.M., Rajeh A., Et al., Effect of the Fe<sub>2</sub>O<sub>3</sub>/TiO<sub>2</sub> Nanoparticles on the Structural, Mechanical, Electrical Properties and Antibacterial Activity of the Biodegradable Chitosan/Polyvinyl Alcohol Blend for Food Packaging, J. Polym. Environ., 30, pp. 3865-3874, (2022)
[10]  
Hezma A.M., Rajeh A., Mannaa M.A., An insight into the effect of zinc oxide nanoparticles on the structural, thermal, mechanical properties and antimicrobial activity of Cs/PVA composite, Colloids Surf. a: Physicochem Eng. Asp., 581, (2019)
123456