A Comparative Study of Bcl-2 Expression in Oral Leukoplakia with Dysplasia, Verrucous Carcinoma, and Oral Squamous Cell Carcinoma

被引：0

作者：

Roy, Bireswar ^{[1
]}

Saxena, Shivani ^{[2
]}

Tripathi, Narayan ^{[3
]}

Sharma, Mridul ^{[4
]}

Rana, Deepmala ^{[5
]}

Pramukh, N. ^{[6
]}

Mehta, Miral ^{[7
]}

机构：

[1] Sudha Rustagi Coll Dent Sci & Res, Dept Oral Pathol & Microbiol, Faridabad, Haryana, India

[2] Shreshth Dent Clin Jhansi, Dept Gen Dent, Jhansi, Uttar Pradesh, India

[3] NHDC&RI, Dept Oral Med & Radiol, Bilaspur, Chhattisgarh, India

[4] McGill Univ, Fac Dent Med & Oral Hlth Sci, Montreal, PQ, Canada

[5] Sudha Rustagi Coll Dent Sci & Res, Dept Oral Pathol Microbiol & Forens Odontol, Faridabad, Haryana, India

[6] Prashant Super Special Hosp, Dept Head & Neck Oncol, Bangalore, Karnataka, India

[7] Karnavati Univ, Karmavati Sch Dent, Dept Pedodont, Gandhinagar, Gujarat, India

来源：

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES | 2024年 / 16卷 / SUPPL 4期

关键词：

Bcl-2; dysplasia; oral squamous cell carcinoma;

D O I：

10.4103/jpbs.jpbs_1190_24

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim:To study the immunohistochemical expression of Bcl-2 in oral leukoplakia with dysplasia, verrucous carcinoma and oral squamous cell carcinoma(OSCC).Methodology:A total of 80 formalin-fixed , paraffin- embedded specimens were selected , amongst them 30 cases of different grades of dysplasia- 10 mild, 10 moderate and 10 severe and 30 oral squamous cell carcinoma of various grades- 10 well differentiated, 10 moderately differentiated and 10 poorly differentiated, 10 verrucous carcinoma had been included in the study. 10 normal buccal mucosa were used as control group.Results:The immunohistochemical expression of Bcl-2 in oral leukoplakia with different grades of dysplasia, in verrucous carcinoma and in different grades of oral squamous cell carcinoma with normal mucosa were compared. Moreover, the expression of Bcl-2 was found to increase significantly between dysplasia and different grades of oral squamous cell carcinoma.Conclusion:The expression of Bcl-2 has always guided the researchers towards mapping the progression of dysplasia as well as malignant transformation at the molecular level.

引用

页码：S3936 / S3938

页数：3

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