Electrochemical deposition of spherulite-like nickel-copper layered double hydroxides on screen-printed carbon electrode for highly sensitive electrochemical detection of chlorpromazine drug

In this work, a novel electrochemical sensor based on spherulite-like Ni0.8Cu0.2layered double hydroxides (Ni0.8Cu0.2-LDH) modified screen-printed carbon electrode was designed and developed for the highly sensitive and selective recognition of chlorpromazine (CPZ). Herein, the electrodeposition method was employed to deposit Ni0.8Cu0.2-LDH on a screen-printed carbon electrode to form an efficient sensing platform for CPZ detection. Subsequently, the fabricated electrode was characterized using Raman spectroscopy, XRD, FT-IR, SEM, and XPS. In addition, the effect of increasing concentrations of CPZ on the current response of the LDH-modified electrode was studied using different electroanalytical techniques, including cyclic voltammetry (CV), square wave voltammetry (SWV), differential pulse voltammetry (DPV), and amperometry. Among all electroanalytical techniques, the DPV-based electrochemical sensor exhibited high sensitivity (0.0357 mu A mu M-1) over a broad linear detection range of 1 nM-100 mu M with a low limit of detection of 50 nM. Moreover, the ability of the developed sensor to accurately detect CPZ in water samples was cross-validated using HPLC, yielding satisfactory results. The LDH-modified electrode also exhibited good repeatability (3.46 %), reproducibility (3.26 %), and stability (20 days). All these attributes make the developed electrochemical sensor an efficient candidate for the real-time detection of CPZ in various water samples with enhanced sensitivity and selectivity.