A multi-institutional randomized phase III trial of lobectomy versus segmentectomy for radiologically solid-predominant non-small cell lung cancer with a ground-glass opacity and tumor diameter > 2 cm and ≤ 3 cm: JCOG2217 (STRONG)

被引：0

作者：

Mitome, Noriko ^{[1
]}

Hattori, Aritoshi ^{[2
]}

Suzuki, Kenji ^{[2
]}

Wakabayashi, Masashi ^{[1
]}

Sekino, Yuta ^{[1
]}

Isaka, Tetsuya ^{[3
]}

Yotsukura, Masaya ^{[4
]}

Aokage, Keiju ^{[5
]}

Fukuda, Haruhiko ^{[1
]}

Watanabe, Shun-ichi ^{[4
]}

机构：

[1] Natl Canc Ctr, Japan Clin Oncol Grp Data Ctr, Operat Off, 5-1-1 Tsukiji,Chuo Ku, Tokyo 1040045, Japan

[2] Juntendo Univ, Sch Med, Dept Gen Thorac Surg, 1-3 Hongo 3-Chome,Bunkyo Ku, Tokyo 1138431, Japan

[3] Kanagawa Canc Ctr, Dept Thorac Surg, 1-1-2 Nakao,Asahi Ku, Yokohama, Kanagawa 2418515, Japan

[4] Natl Canc Ctr, Dept Thorac Surg, 5-1-1Tsukiji,Chuo Ku, Tokyo 1040045, Japan

[5] Natl Canc Ctr Hosp East, Div Thorac Surg, 6-5-1 Kashiwanoha, Kashiwa, Chiba 2778577, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2025年

关键词：

non-small cell lung cancer; segmentectomy; solid-predominant tumor; ground glass opacity; thin-slice computed tomography; SURGICAL COMPLICATIONS; COMPUTED-TOMOGRAPHY; SURVIVAL; ADENOCARCINOMA; CLASSIFICATION; COMPONENT;

D O I：

10.1093/jjco/hyaf104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lobectomy has been the standard surgical procedure for clinical stage IA non-small cell lung cancer (NSCLC) since the results of a randomized trial in 1995. However, recent phase III trials have demonstrated the efficacy of segmentectomy for small NSCLC. Segmentectomy has become one of the standard treatments for peripheral lung cancers with a tumor diameter of <= 2 cm and further expansion of the indication for segmentectomy is considered. We planned this trial to confirm the non-inferiority of segmentectomy to lobectomy in terms of overall survival in patients with solid-predominant NSCLC with ground-glass opacity and > 2 cm and <= 3 cm in tumor diameter. Pure-solid tumors will be excluded because of their highly malignant characteristics. The primary endpoint is overall survival. A total of 515 patients from 53 institutions will be enrolled over 5 years. The trial has been registered in the Japan Registry of Clinical Trials (study number: jRCTs1030240027).

引用

页数：5

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