Assisted reproductive technology in young BRCA carriers with a pregnancy after breast cancer: An international cohort study

被引：0

作者：

Magaton, Isotta Martha ^{[1
,2
]}

Blondeaux, Eva ^{[3
]}

Hamy, Anne-Sophie ^{[4
]}

Linn, Sabine ^{[5
,6
]}

Bernstein-Molho, Rinat ^{[7
]}

Peccatori, Fedro A. ^{[8
]}

Ferrari, Alberta ^{[9
,10
]}

Carrascoi, Estela ^{[11
]}

Paluch-Shimon, Shani ^{[12
,13
]}

Agostinetto, Elisa ^{[14
]}

Venturelli, Marta ^{[15
]}

Luis, Ines Maria Vaz ^{[16
]}

Rodriguez-Wallberg, Kenny A. ^{[17
]}

Kim, Hee Jeong ^{[18
]}

Sorouri, Kimia ^{[19
,20
]}

Renaud, Tiphaine ^{[21
]}

Moore, Halle C. F. ^{[22
]}

Cui, Wanda ^{[23
,24
]}

Bajpa, Jyoti ^{[25
]}

Rousset-Jablonski, Christine ^{[26
,27
,28
]}

De Marchis, Laura ^{[29
,30
]}

Yerushalmi, Rinat ^{[31
]}

Wong, Stephanie M. ^{[32
,33
]}

Han, Sileny ^{[34
]}

Phillips, Kelly-Anne ^{[24
,25
,35
]}

Pogoda, Katarzyna ^{[36
]}

Puglisi, Fabio ^{[37
,38
]}

Chirco, Alessandra ^{[39
]}

Duhoux, Francois P. ^{[40
,41
]}

Meattini, Icro ^{[42
,43
]}

Villarreal-Garza, Cynthia ^{[44
]}

Vernieri, Claudio ^{[45
,46
]}

Bruzzone, Marco ^{[3
]}

Demeestere, Isabelle ^{[47
,48
]}

Azim Jr, Hatem A. ^{[49
]}

Partridge, Ann H. ^{[19
]}

Lambertini, Matteo ^{[1
,50
,51
]}

机构：

[1] IRCCS Osped Policlin San Martino, Med Oncol Dept, UOC Clin Oncol Med, Genoa, Italy

[2] Inselspital Bern, Univ Women Hosp, Bern, Switzerland

[3] IRCCS Osped Policlin San Martino, UO Epidemiol Clin, Genoa, Italy

[4] Univ Paris Cite, Inst Curie, Dept Med Oncol, Paris, France

[5] Netherlands Canc Inst NKI, Dept Mol Pathol, Amsterdam, Netherlands

[6] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands

[7] Tel Aviv Univ, Danek Gertner Inst Human Genet, Susanne Levy Gertner Oncogenet Unit, Chaim Sheba Med Ctr, Tel Hashomer, Israel

[8] European Inst Oncol IRCCS, Gynaecol Oncol Program, Milan, Italy

[9] Fdn IRCCS Policlin San Matteo, Hereditary Breast & Ovarian Canc HBOC Unit & Gen S, Surg Dept, Pavia, Italy

[10] Univ Pavia, Pavia, Italy

[11] Vall dHebron Univ Hosp, Vall dHebron Inst Oncol VHIO, Med Oncol Dept, Hereditary Canc Genet Unit, Barcelona, Spain

[12] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

[13] Hebrew Univ Jerusalem, Hadassah Univ Hosp, Breast Oncol Unit, Sharett Inst Oncol, Jerusalem, Israel

[14] Univ Libre Bruxelles ULB, Hop Univ Bruxelles HUB, Inst Jules Bordet, Acad Trials Promoting Team, Brussels, Belgium

[15] Azienda Osped Univ Modena, Dept Oncol & Haematol, Modena, Italy

[16] Gustave Roussy, INSERM, Canc Survivorship Program, Unit 981,Mol Predictors & New Targets Oncol, Villejuif, France

[17] Karolinska Univ Hosp, Karolinska Inst & Reprod Med, Dept Oncol Pathol, Stockholm, Sweden

[18] Univ Ulsan, Coll Med, Dept Surg, Div Breast Surg,Asan Med Ctr, Seoul, South Korea

[19] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[20] Univ Alberta, Dept Gynaecol Obstet & Gynaecol, Edmonton, AB, Canada

[21] Bergonie Inst, Canc Genet Unit, Bordeaux, France

[22] Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH USA

[23] Peter Maallum Canc Ctr, Dept Med Oncol, Melbourne, Vic, Australia

[24] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[25] Homi Bhabha Natl Inst HBNI, Tata Mem Ctr, Mumbai, India

[26] Leon Berard Canc Ctr, Dept Surg, Lyon, France

[27] Hop Femme Mere Enfant, Lyon, France

[28] INSERM, U 1290, RESHAPE, Lyon, France

[29] Univ Roma La Sapienza, Dept Radiol Oncol & Pathol Sci, Div Med Oncol, Rome, Italy

[30] Umberto I Univ Hosp, Med Oncol Dept Hematol Oncol & Dermatol, Rome, Italy

[31] Tel Aviv Univ, Davidoff Ctr, Rabin Med Ctr, Petah Tiqwa, Israel

[32] Jewish Gen Hosp, Stroll Canc Prevent Ctr, Montreal, PQ, Canada

[33] McGill Univ, Med Sch, Montreal, PQ, Canada

[34] Univ Hosp Leuven, Leuven Canc Inst, Multidisciplinary Breast Ctr, Dept Gen Med Oncol, Leuven, Belgium

[35] Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia

[36] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Breast Canc & Reconstruct Surg, Roentgena 5, Warsaw, Poland

[37] Ctr Riferimento Oncol Aviano CRO IRCCS, Dept Med Oncol, Dipartimento Oncol Med, Aviano, Italy

[38] Univ Udine, Dept Med, Udine, Italy

[39] ASST Papa Giovanni XXIII, SC Oncol, Bergamo, Italy

[40] UCLouvain, Clin Univ St Luc, Dept Med Oncol, King Albert II Canc Inst, Brussels, Belgium

[41] UCLouvain, Inst Rech Expt & Clin Pole MIRO, Brussels, Belgium

[42] Univ Florence, Dept Expt & Clin Biomed Sci M Serio, Florence, Italy

[43] Azienda Osped Univ Careggi, Oncol Dept, Breast Unit, Radiat Oncol Unit, Florence, Italy

[44] TecSalud, Tecnol Monterrey, Hosp Zambrano Hell, Breast Canc Ctr, Monterrey, Mexico

[45] Fdn IRCCS Ist Nazl Tumori, Med Oncol Dept, Breast Unit, Milan, Italy

[46] Univ Milan, Oncol & Haematol Oncol Dept, Milan, Italy

[47] HUB Erasme, Fertil Clin, Dept Obstet & Gynecol, Brussels, Belgium

[48] Univ Libre Bruxelles ULB, Res Lab Human Reprod, Brussels, Belgium

[49] Cairo Cure Oncol Ctr, Cairo, Egypt

[50] Univ Genoa, Sch Med, Dept Internal Med & Med Specialties DiMI, Genoa, Italy

来源：

EUROPEAN JOURNAL OF CANCER | 2025年 / 222卷

关键词：

Assisted reproductive technology (ART); Breast cancer; Germline BRCA1/2 pathogenic variants; Oncofertility; Pregnancy; HEREDITARY BREAST; OVARIAN RESERVE; FERTILITY; IMPACT; WOMEN; MUTATIONS; THERAPY;

D O I：

10.1016/j.ejca.2025.115434

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Very limited data exist on assisted reproductive technology (ART) use in BRCA1/2 carriers conceiving after breast cancer. This study aimed to investigate the safety of ART to achieve a pregnancy after breast cancer in BRCA1/2 carriers. Methods: This is an international, hospital-based, retrospective cohort study including BRCA1/2 carriers with a pregnancy after prior breast cancer diagnosis at < 40 years of age between 2000 and 2020. Outcomes were compared between young BRCA1/2 carriers who conceived using ART and those who conceived spontaneously. Results: Among 543 BRCA1/2 carriers with a pregnancy after breast cancer, 436 conceived spontaneously and 107 using ART. Of 107 pregnancies achieved with ART, 45 (42.1 %) were obtained using oocytes/embryo cryopreserved at diagnosis, 33 (30.8 %) after controlled ovarian stimulation for in-vitro-fertilization/ intracytoplasmic sperm injection or ovulation induction for intrauterine insemination or planned intercourse after anticancer treatments, 21 (19.6 %) after oocyte donation, while for 8 (7.5 %) patients type of ART was missing. Compared to patients in the no-ART group, those in the ART group were older at the time of conception, had more frequently hormone receptor-positive breast cancer and a longer median time from cancer diagnosis to conception. At a median follow-up of 5.2 years after conception, no apparent detrimental effect of ART on disease-free survival was observed (adjusted HR=0.72, 95 % CI 0.39-1.34). Conclusion: In young BRCA1/2 carriers with a pregnancy after breast cancer, ART use did not appear to be associated with increased risk of DFS events.

引用

页数：8

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