Psychiatric Genomics 2025 State of the Art and the Path Forward

被引：0

作者：

Liu, Chunyu ^{[1
]}

Zhang, Chunling ^{[2
]}

Glatt, Stephen J. ^{[1
]}

机构：

[1] SUNY Upstate Med Univ, Dept Psychiat, 505 Irving Ave, Syracuse, NY 13210 USA

[2] SUNY Upstate Med Univ, Dept Neurosci & Physiol, 505 Irving Ave, Syracuse, NY 13210 USA

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 2025年 / 48卷 / 02期

关键词：

Psychiatry; Genetics; Genomics; Review; SINGLE-CELL ATLAS; GENE-EXPRESSION; ENHANCER ACTIVITY; CAUSAL VARIANTS; SCHIZOPHRENIA; TRAIT; DYSREGULATION; KNOCKDOWN; SIGNALS; LOCUS;

D O I：

10.1016/j.psc.2025.01.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

center dot Genetic studies identified hundreds of genetic variants associated with mental illnesses, with a significant overlap across disorders challenging traditional classifications and calling for functional interpretation. center dot Mapping of expression quantitative trait loci in brain and neural cells has revealed functional elements regulating gene expression. Some of these regulations influence psychiatric pathology. center dot Single-cell and other new technologies and cellular models have revolutionized functional studies of genetic variants and their associated genes in the human brain. center dot Major databases and websites of functional genomics are cataloged here for reference. center dot The complexity of psychiatric disorders calls for data from large cohorts and diverse populations, interdisciplinary and international collaboration, and novel technologies.

引用

页码：217 / 240

页数：24

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