Evaluation of hepatitis B vaccination strategy based on age heterogeneity model

China is one of the countries with highest burden of hepatitis B in the world, the number of new infections each year is at a high level and increases year by year. The number of infections in people aged 15 years and older accounts for 97.5% of all cases. Vaccination is the most effective way of reducing the risk of disease transmission. It is essential to assess the role of vaccination or booster vaccination in adult populations. In this paper, the hepatitis B cases data in different age groups were analyzed, an age heterogeneous hepatitis B transmission dynamics model including multiple age groups and vaccination was established. Fitting the cumulative case data of hepatitis B and obtaining the model parameters. Sensitivity analysis of the basic reproduction number R0 shows that vaccination of the population aged 25-70 can significantly reduce the number of hepatitis B cases. Exploring the impact of different vaccination immunization strategies on the number of hepatitis B cases, we get that it is the most effective to vaccinate people aged 15-70, which can reduce the cumulative number of hepatitis B cases by about 60%. Only reducing the contact between people does not help to significantly reduce the number of hepatitis B cases, but vaccination helps to greatly reduce the number of hepatitis B cases.