Chromatin Structure Around Long Non-Coding RNA (lncRNA) Genes in Schistosoma mansoni Gonads

被引：0

作者：

Augusto, Ronaldo C. ^{[1
]}

Quack, Thomas ^{[2
]}

Grevelding, Christoph G. ^{[2
]}

Grunau, Christoph ^{[1
]}

机构：

[1] Univ Perpignan, Univ Montpellier, IHPE, CNRS, Via Domitia, F-66860 Perpignan, France

[2] Justus Liebig Univ, Inst Parasitol, BFS, D-35392 Giessen, Germany

来源：

NON-CODING RNA | 2025年 / 11卷 / 02期

基金：

英国惠康基金;

关键词：

Schistosoma mansoni; posttranslational histone modifications; long non-coding RNA; chromatin; gonads;

D O I：

10.3390/ncrna11020025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we employed a total of eight distinct modifications of histone proteins (H3K23ac, H3K27me3, H3K36me3, H3K4me3, H3K9ac, H3K9me3, H4K12ac, and H4K20me1) to discern the various chromatin colors encompassing lncRNA genes in both mature and immature gonads of the human parasite Schistosoma mansoni. Our investigation revealed that these chromatin colors exhibit a tendency to aggregate based on the similarities in their metagene shapes, leading to the formation of less than six distinct clusters. Moreover, these clusters can be further grouped according to their resemblances by shape, which are co-linear with specific regions of the genes, and potentially associated with transcriptional stages.

引用

页数：9

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