Research Progress on the Structure-activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer

被引：0

作者：

Yao, Jiacheng ^{[1
,2
]}

Zhu, Feng ^{[3
]}

Feng, Yikun ^{[1
,2
]}

Gu, Chen ^{[1
,2
]}

Wang, Tianyu ^{[2
]}

Li, Xinyu ^{[2
]}

Yang, Hao ^{[2
]}

Hu, Xiamin ^{[1
,2
]}

Bonnet, Pierre-Antoine ^{[4
]}

Meng, Xiangguo ^{[2
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Grad Sch, Shanghai 201203, Peoples R China

[2] Shanghai Univ Med & Hlth Sci, Fac Pharm, Shanghai 201318, Peoples R China

[3] Shanghai Haini Pharmaceut Co Ltd, Yangzijiang Pharmaceut Grp, Shanghai 201318, Peoples R China

[4] Montpellier Univ, Fac Pharm, IBMM, CNRS,ENSCM, F-34093 Montpellier, France

来源：

MOLECULES | 2025年 / 30卷 / 08期

关键词：

flavonoids; anti-tumor mechanism; structure-activity relationships; natural products; derivate; lung cancer; CELL-CYCLE ARREST; IN-VITRO; APOPTOSIS; INHIBITION; GROWTH; PROTOAPIGENONE; ANTIOXIDANT; BAICALEIN; ANALOGS; AGENTS;

D O I：

10.3390/molecules30081827

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. The difficulty in early diagnosis, combined with the tendency for tumor invasion and metastasis, creates significant challenges for current therapeutic approaches. Additionally, the pharmaceutical agents currently used to treat NSCLC often come with severe side effects and can lead to drug resistance. As a result, there is an urgent need to develop new therapeutic agents with fewer side effects that can effectively overcome resistance mechanisms. Flavonoids, a prominent class of natural compounds, have shown promise in preventing and treating various cancers. By structurally optimizing flavonoids, it is possible to enhance their anticancer activity and improve their pharmacokinetic properties. This article reviews the different mechanisms of action and structure-activity relationships (SARs) of flavonoid derivatives in treating NSCLC, aiming to provide a scientific foundation for developing new therapeutic agents.

引用

页数：18

共 96 条

[1]

Abed SN, 2019, ADV PHARM PROD DEVL, P685, DOI 10.1016/B978-0-12-817909-3.00017-0

[2] Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives [J].

Alizadeh, Seyedeh Roya ;

Savadkouhi, Niloofar ;

Ebrahimzadeh, Mohammad Ali .

EXPERT OPINION ON DRUG DISCOVERY, 2023, 18 (10) :1117-1132

[3] Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future [J].

Alzeibak, Razan ;

Mishchenko, Tatiana A. ;

Shilyagina, Natalia Y. ;

Balalaeva, Irina V. ;

Vedunova, Maria V. ;

Krysko, Dmitri V. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 (01)

[4] Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies [J].

Arya, Girish Chandra ;

Kaur, Kamalpreet ;

Jaitak, Vikas .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 221

[5] Exploring Mitochondria-Mediated Intrinsic Apoptosis by New Phytochemical Entities: An Explicit Observation of Cytochrome c Dynamics on Lung and Melanoma Cancer Cells [J].

Arya, Jayadev S. ;

Joseph, Manu M. ;

Sherin, Daisy R. ;

Nair, Jyothi B. ;

Manojkumar, Thanathu K. ;

Maiti, Kaustabh K. .

JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (17) :8311-8329

[6] Antiviral activities of flavonoids [J].

Badshah, Syed Lal ;

Faisal, Shah ;

Muhammad, Akhtar ;

Poulson, Benjamin Gabriel ;

Emwas, Abdul Hamid ;

Jaremko, Mariusz .

BIOMEDICINE & PHARMACOTHERAPY, 2021, 140

[7] A Synthetic Naringenin Derivative, 5-Hydroxy-7, 4′-diacetyloxyflavanone-N-phenyl Hydrazone (N101-43), Induces Apoptosis through Up-regulation of Fas/FasL Expression and Inhibition of PI3K/Akt Signaling Pathways in Non-Small-Cell Lung Cancer Cells [J].

Bak, Yesol ;

Kim, Heejong ;

Kang, Jeong-Woo ;

Lee, Dong Hun ;

Kim, Man Sub ;

Park, Yun Sun ;

Kim, Jung-Hee ;

Jung, Kang-Yeoun ;

Lim, Yoongho ;

Hong, Jintae ;

Yoon, Do-Young .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (18) :10286-10297

[8] The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation [J].

Calis, Zehra ;

Mogulkoc, Rasim ;

Baltaci, Abdulkerim Kasim .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2020, 20 (15) :1475-1488

[9] Baicalein: A review on its anti-cancer effects and mechanisms in lung carcinoma [J].

Chandrashekar, Naveenkumar ;

Pandi, Anandakumar .

JOURNAL OF FOOD BIOCHEMISTRY, 2022, 46 (09)

[10] Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo [J].

Chang, Hsueh-Ling ;

Su, Jinu-Huang ;

Yeh, Yao-Tsung ;

Lee, Yi-Chen ;

Chen, Huey-May ;

Wu, Yang-Chang ;

Yuan, Shyng-Shiou F. .

CANCER LETTERS, 2008, 267 (01) :85-95

← 1 2 3 4 5 6 7 8 9 10 →