Pre-transplant myosteatosis worsens the survival after liver transplantation: A systematic review and meta-analysis

Objective: Sarcopenia worsens survival after liver transplantation (LT). However, it remains unclear whether myosteatosis, a pathological phenomenon involving excess fat deposition, also causes adverse effects. We performed a meta-analysis to evaluate the effect of myosteatosis on survival in this patient population. Methods: We searched PubMed, EMBASE, Web of Science, and Cochrane databases through March 30, 2025 for articles that focused on the association between myosteatosis and post-LT mortality. The Newcastle-Ottawa Scale was used to assess the quality of the studies. The primary outcome was mortality rate. Meta-analyses were performed using Review Manager software. Study quality, publication bias, and subgroup analyses were performed. Result: 28 studies involving 7068 patients were included. The studies were of moderate-to-high quality. The pooled results suggested that myosteatosis as a categorical variable was an independent predictor of mortality, both in univariate analyses (hazard ratio[HR] = 1.80, 95%CI 1.59-2.05) and multifactorial analyses (HR = 1.69, 95%CI 1.51-1.89). Similar results were found when myosteatosis was treated as a continuous variable. Further pooling of data comparing patients with and without myosteatosis within 6-month, one, three, and five years of follow-up (odds ratio[OR] = 5.49, 95%CI 3.69-8.17, OR = 1.93, 95% CI: 1.55-2.41, OR = 1.62, 95%CI 1.30-2.0 0, and OR = 1.68, 95%CI 1.28-2.19, respectively) also suggested a high mortality risk in myosteatosis patients. Finally, sensitivity analyses based on the different definitions of myosteatosis confirmed these results. In addition, patients with myosteatosis had significantly increased ICU stay (mean difference[MD] = 7.86 days; 95 % CI, 2.41-13.30), hospital stay (MD = 2.04 days, 95 % CI, 0.56-3.53), and more post-LT complications (OR = 2.35, 95 % CI 1.93-2.87) than those without myosteatosis. Conclusions: Our results revealed that myosteatosis is associated with an increased risk of mortality in patients undergoing LT. These findings indicate that myosteatosis can be a tool to identify high-risk patients and make informed clinical decisions during perioperative management. (c) 2025 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.