A case report and literature review: leiomyosarcoma or perivascular epithelioid cell neoplasm?

被引：0

作者：

Chen, Zheng ^{[1
,2
,3
]}

Zheng, Xuan ^{[1
,2
,3
]}

Lin, Qin ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Sch Med, Dept Obstet & Gynecol, Shanghai, Peoples R China

[2] Int Peace Matern & Child Hlth Hosp, Shanghai Key Lab Embryo Original Dis, Shanghai, Peoples R China

[3] Int Peace Matern & Child Hlth Hosp, Shanghai Municipal Key Clin Specialty, Shanghai, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

基金：

中国国家自然科学基金;

关键词：

case report; uterine neoplasm; leiomyosarcoma; perivascular epithelioid cell neoplasm; diagnosis; UTERINE LEIOMYOSARCOMA; SARCOMAS; TUMORS;

D O I：

10.3389/fonc.2024.1499403

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The distinction between a uterine leiomyosarcoma (uLMS) and a perivascular epithelioid cell neoplasm (PEComa) can be quite challenging. Here we report a 39-year-old woman who underwent a hysteroscopic myomectomy. An intraoperative frozen section pathological examination revealed that the mass was likely to be a mesenchymal malignancy. After consultation with her family, a total hysterectomy and bilateral salpingo-oophorectomy were performed. Postoperative pathological examinations suggested leiomyosarcoma but a malignant PEComa cannot be completely excluded. Combining the present case and prior studies, we summarized the clinical manifestations, pathological features, genomic characterization, and treatment of LMS and PEComa.

引用

页数：4

共 19 条

[1] Dichotomy of Genetic Abnormalities in PEComas With Therapeutic Implications [J].

Agaram, Narasimhan P. ;

Sung, Yun-Shao ;

Zhang, Lei ;

Chen, Chun-Liang ;

Chen, Hsiao-Wei ;

Singer, Samuel ;

Dickson, Mark A. ;

Berger, Michael F. ;

Antonescu, Cristina R. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2015, 39 (06) :813-825

[2] A Clinicopathologic and Molecular Characterization of Uterine Sarcomas Classified as Malignant PEComa [J].

Anderson, William J. ;

Dong, Fei ;

Fletcher, Christopher D. M. ;

Hirsch, Michelle S. ;

Nucci, Marisa R. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2023, 47 (05) :535-546

[3] TFE3-Rearranged PEComa/PEComa-like Neoplasms Report of 25 New Cases Expanding the Clinicopathologic Spectrum and Highlighting its Association With Prior Exposure to Chemotherapy [J].

Argani, Pedram ;

Gross, John M. ;

Baraban, Ezra ;

Rooper, Lisa M. ;

Chen, Suping ;

Lin, Ming-Tseh ;

Gocke, Christopher ;

Agaimy, Abbas ;

Lotan, Tamara ;

Suurmeijer, Albert J. H. ;

Antonescu, Cristina R. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2024, 48 (07) :777-789

[4] Status of the Current Treatment Options and Potential Future Targets in Uterine Leiomyosarcoma: A Review [J].

Asano, Hiroshi ;

Isoe, Toshiyuki ;

Ito, Yoichi M. ;

Nishimoto, Naoki ;

Watanabe, Yudai ;

Yokoshiki, Saki ;

Watari, Hidemichi .

CANCERS, 2022, 14 (05)

[5]

Bao LR, 2019, INT J CLIN EXP PATHO, V12, P4380

[6] Uterine PEComas: correlation between melanocytic marker expression and TSC alterations/TFE3 fusions [J].

Bennett, Jennifer A. ;

Ordulu, Zehra ;

Pinto, Andre ;

Wanjari, Pankhuri ;

Antonescu, Cristina R. ;

Ritterhouse, Lauren L. ;

Oliva, Esther .

MODERN PATHOLOGY, 2022, 35 (04) :515-523

[7] Perivascular epithelioid cell tumors (PEComa) of the gynecologic tract [J].

Bennett, Jennifer A. ;

Oliva, Esther .

GENES CHROMOSOMES & CANCER, 2021, 60 (03) :168-179

[8] Interrogating the Genomic Landscape of Uterine Leiomyosarcoma: A Potential for Patient Benefit [J].

Dall, Genevieve, V ;

Hamilton, Anne ;

Ratnayake, Gayanie ;

Scott, Clare ;

Barker, Holly .

CANCERS, 2022, 14 (06)

[9]

Fadare Oluwole, 2008, Int Semin Surg Oncol, V5, P7, DOI 10.1186/1477-7800-5-7

[10] Perivascular epithelioid cell tumors (PEComa) of the female genital tract: A challenging question for gynaecologic oncologist and pathologist [J].

Gadducci, Angiolo ;

Zannoni, Gian Franco .

GYNECOLOGIC ONCOLOGY REPORTS, 2020, 33

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