Combination locoregional and systemic therapies in hepatocellular carcinoma

被引：6

作者：

Zhong, Bin-Yan ^{[1
,2
]}

Fan, Wenzhe ^{[3
]}

Guan, Justin J.

Peng, Zhenwei ^{[4
,5
]}

Jia, Zhongzhi ^{[7
]}

Jin, Haojie ^{[8
]}

Jin, Zhi-Cheng ^{[1
]}

Chen, Jian-Jian ^{[1
,6
]}

Zhu, Hai-Dong ^{[1
]}

Teng, Gao-Jun ^{[1
]}

机构：

[1] Southeast Univ, Zhongda Hosp, Ctr Intervent Radiol & Vasc Surg, Med Sch,Nurturing Ctr,Jiangsu Prov State Lab AI Im, Nanjing 210009, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Intervent Radiol, Suzhou, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Oncol, Guangzhou, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 1, Canc Ctr, Dept Radiat Oncol, Guangzhou, Peoples R China

[5] Sun Yat Sen Univ, Affiliated Hosp 1, Inst Precis Med, Guangzhou, Peoples R China

[6] Cleveland Clin, Dept Radiol, Div Intervent Radiol, Cleveland, OH USA

[7] Nanjing Med Univ, Affiliated Changzhou Peoples Hosp 2, Dept Intervent & Vasc Surg, Changzhou, Peoples R China

[8] Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, Sch Med,State Key Lab Syst Med Canc, Shanghai, Peoples R China

来源：

LANCET GASTROENTEROLOGY & HEPATOLOGY | 2025年 / 10卷 / 04期

基金：

中国国家自然科学基金;

关键词：

RANDOMIZED CONTROLLED-TRIAL; INTERNAL RADIATION-THERAPY; TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; AWAITING LIVER-TRANSPLANTATION; VEIN TUMOR THROMBOSIS; T-CELL SUBSETS; RADIOFREQUENCY ABLATION; TRANSARTERIAL CHEMOEMBOLIZATION; DOUBLE-BLIND; PHASE-III;

D O I：

10.1016/S2468-1253(24)00247-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Locoregional therapies play a fundamental role in the treatment of patients with early and intermediate and locally advanced hepatocellular carcinomas. With encouraging recent advances in immunotherapy-based systemic therapies, locoregional therapies are being both promoted and challenged by new systemic therapy options. Combined locoregional and systemic therapies might enhance treatment outcomes compared with either option alone. This Series paper summarises the existing data on locoregional and systemic therapies for hepatocellular carcinoma, and discusses evidence from studies investigating their combination with a focus on their synergistic efficacy and safety.

引用

页码：369 / 386

页数：18

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