Chlorine gas induced acute respiratory distress syndrome due to pool shock

被引:0
作者
Bleifuss, William [1 ]
Pepin, Lesley [1 ,2 ]
Lock, Sarah [2 ]
Kaluzniak, Heather [3 ]
Kempainen, Robert [3 ]
机构
[1] Minnesota Reg Poison Ctr, Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA
[2] Hennepin Cty Med Ctr, Dept Emergency Med, Minneapolis, MN USA
[3] Hennepin Cty Med Ctr, Dept Crit Care, Minneapolis, MN USA
关键词
Chlorine gas; ARDS; Hypochlorite; Respiratory failure; INHALATION; EXPOSURE;
D O I
10.1016/j.ajem.2025.04.001
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Chlorine gas is a known pulmonary irritant with potential to cause significant lung injury. Most severe cases stem from industrial accidents or chemical warfare, and while exposure is common with chlorinated household cleaners, life threatening events are rare. A 75-year-old male developed acute respiratory distress syndrome (ARDS) following an accidental chlorine exposure after mixing calcium hypochlorite powder with water in his sink, triggering an explosion with chlorine gas release. He rapidly developed bronchospasm, pulmonary edema and respiratory failure within hours of exposure, in addition to severe chemical conjunctivitis. He was rapidly intubated, received bronchodilators, intravenous dexamethasone and inhaled epoprostenol, and underwent prone positioning. Targeted therapy for chlorine gas induced lung injury is limited. Despite a rapid decline over his initial clinical course, and prognostic markers all portending a poor outcome, aggressive management of his lung injury with standard ARDS care proved to be effective, and the patient made an excellent recovery. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
引用
收藏
页码:236e3 / 236e5
页数:3
相关论文
共 14 条
[1]   The effect of nebulized NaHCO3 treatment on "RADS" due to chlorine gas inhalation [J].
Aslan, Sahin ;
Kandis, Hayati ;
Akgun, Metin ;
Cakir, Zeynep ;
Inandi, Tacettin ;
Goerguener, Metin .
INHALATION TOXICOLOGY, 2006, 18 (11) :895-900
[2]   Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries [J].
Bellani, Giacomo ;
Laffey, John G. ;
Pham, Tai ;
Fan, Eddy ;
Brochard, Laurent ;
Esteban, Andres ;
Gattinoni, Luciano ;
van Haren, Frank ;
Larsson, Anders ;
McAuley, Daniel F. ;
Ranieri, Marco ;
Rubenfeld, Gordon ;
Thompson, B. Taylor ;
Wrigge, Hermann ;
Slutsky, Arthur S. ;
Pesenti, Antonio .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (08) :788-800
[3]  
Jones R, 2015, Lung function after acute chlorine exposure, V134, P1190, DOI [10.1164/arrd.1986.134.6.1190, DOI 10.1164/ARRD.1986.134.6.1190]
[4]  
Morim A., 2019, Chlorine Gas Toxicity
[5]   Human chlorine gas exposition and its management - an umbrella review on human data [J].
Nambiema, Aboubakari ;
Coyo, Gabrielle ;
Barbe-Richaud, Jean-Baptiste ;
Blottiaux, Jeremy ;
Retiere-Dore, Nicolas ;
Sembajwe, Grace ;
Descatha, Alexis .
CRITICAL REVIEWS IN TOXICOLOGY, 2022, 52 (01) :32-50
[6]   An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome An Official American Thoracic Society Clinical Practice Guideline [J].
Qadir, Nida ;
Sahetya, Sarina ;
Munshi, Laveena ;
Summers, Charlotte ;
Abrams, Darryl ;
Beitler, Jeremy ;
Bellani, Giacomo ;
Brower, Roy G. ;
Burry, Lisa ;
Chen, Jen-Ting ;
Hodgson, Carol ;
Hough, Catherine L. ;
Lamontagne, Francois ;
Law, Anica ;
Papazian, Laurent ;
Tai Pham ;
Rubin, Eileen ;
Siuba, Matthew ;
Telias, Irene ;
Patolia, Setu ;
Chaudhuri, Dipayan ;
Walkey, Allan ;
Rochwerg, Bram ;
Fan, Eddy .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209 (01) :24-36
[7]   THE PULMONARY SEQUELAE ASSOCIATED WITH ACCIDENTAL INHALATION OF CHLORINE GAS [J].
SCHWARTZ, DA ;
SMITH, DD ;
LAKSHMINARAYAN, S .
CHEST, 1990, 97 (04) :820-825
[8]  
Sever Mustafa, 2009, J Clin Med Res, V1, P274, DOI 10.4021/jocmr2009.12.1283
[9]   Severe lung injury after exposure to chloramine gas from household cleaners [J].
Tanen, DA ;
Graeme, KA ;
Raschke, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (11) :848-849
[10]   Emergency management of chlorine gas exposure - a systematic review [J].
Tuong, Alice Huynh ;
Despreaux, Thomas ;
Loeb, Thomas ;
Salomon, Jerome ;
Megarbane, Bruno ;
Descatha, Alexis .
CLINICAL TOXICOLOGY, 2019, 57 (02) :77-98