CA-DTPA-INDUCED FETAL DEATH AND MALFORMATION IN MICE

被引：17

作者：

FISHER, DR ^{[1
]}

CALDER, SE ^{[1
]}

MAYS, CW ^{[1
]}

TAYLOR, GN ^{[1
]}

机构：

[1] UNIV UTAH, COLL MED, RADIOL LAB, SALT LAKE CITY, UT 84132 USA

来源：

TERATOLOGY | 1976年 / 14卷 / 02期

关键词：

D O I：

10.1002/tera.1420140202

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Increased fetal mortality and congenital malformation were induced in mice by Ca-DTPA [calcium trisodium diethylenetriaminepentaacetate], a chelate widely used for the removal of internally deposited Pu in human beings. Mated C57BL/Do female mice were given 5 daily injections of 720-2880 .mu.mol/kg Ca-DTPA during early, mid or late gestation. Damage probably occurred as a result of the depletion of Ca-DTPA of Zn and Mn, trace elements essential to growth and development. It seems likely that Ca-DTPA can damage human fetuses. A much safer chelate, Zn-DTPA [zinc trisodium diethylenetriaminepentaacetate], is recommended for the treatment of accidental Pu contamination.

引用

页码：123 / 127

页数：5

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