Management of iron deficiency in children, adults, and pregnant individuals: evidence-based and expert consensus recommendations

被引：1

作者：

Benson, Ashley E. ^{[1
]}

Lo, Jamie O. ^{[1
,2
]}

Achebe, Maureen O. ^{[3
]}

Aslan, Jorgeane S. ^{[4
]}

Auerbach, Michael ^{[5
]}

Bannow, Bethany T. Samuelson ^{[4
]}

Boller, Marie J. ^{[1
]}

Deloughery, Thomas G. ^{[4
]}

Dingman, Jacquelin ^{[6
]}

Van Doren, Layla ^{[8
]}

Dy, Geolani W. ^{[2
]}

Ford, Patricia A. ^{[9
]}

Freed, Jason A. ^{[10
]}

Georgieff, Michael K. ^{[11
]}

Haley, Kristina M. ^{[12
]}

Han, Chloe, I ^{[13
]}

Lewkowitz, Adam K. ^{[14
]}

Martens, Kylee L. ^{[4
]}

Means Jr, Robert T. ^{[15
,16
,17
]}

Nemeth, Elizabeta ^{[18
]}

Olson, Sven R. ^{[6
]}

Powers, Jacquelyn M. ^{[19
]}

Prewitt, Kristin C. ^{[1
]}

Richards, Toby ^{[20
]}

Rockey, Don C. ^{[21
]}

Roeland, Eric J. ^{[6
]}

Ryan, Kimberly S. ^{[1
]}

Al-Samkari, Hanny ^{[22
]}

Sholzberg, Michelle ^{[23
,24
]}

Tuuli, Methodius G. ^{[14
]}

Weyand, Angela C. ^{[25
]}

Zeller, Michelle P. ^{[26
,27
]}

Totten, Annette M. ^{[7
]}

Ivlev, Ilya ^{[7
]}

Shatzel, Joseph J. ^{[4
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Urol, Portland, OR USA

[3] Harvard Med Sch, Brigham & Womens Hosp, Div Hematol, Boston, MA USA

[4] Oregon Hlth & Sci Univ, Knight Canc Inst, Div Hematol & Med Oncol, Portland, OR USA

[5] Georgetown Univ, Sch Med, Dept Med, Washington, DC USA

[6] Knight Canc Inst, Portland, OR USA

[7] Oregon Hlth & Sci Univ, Pacific Northwest Evidence Based Practice Ctr, Portland, OR USA

[8] Yale Sch Med, Dept Med, Sect Hematol, New Haven, CT USA

[9] Hosp Univ Penn, Abramson Canc Ctr, Philadelphia, PA USA

[10] Beth Israel Deaconess Med Ctr, Div Hematol & Hematol Malignancies, Boston, MA USA

[11] Univ Minnesota, Dept Pediat, Div Neonatol, Minneapolis, MN 55455 USA

[12] Oregon Hlth & Sci Univ, Div Pediat Hematol & Oncol, Portland, OR USA

[13] Oregon Hlth & Sci Univ, Div Pediat Crit Care, Dept Pediat, Portland, OR USA

[14] Brown Univ, Warren Alpert Med Sch, Dept Obstet & Gynecol, Div Maternal Fetal Med, Providence, RI 02912 USA

[15] East Tennessee State Univ, James H Quillen Coll Med, Dept Internal Med, Johnson City, TN USA

[16] East Tennessee State Univ, James H Quillen Coll Med, Dept Med Educ, Johnson City, TN USA

[17] East Tennessee State Univ, James H Quillen Coll Med, Dept Pathol, Johnson City, TN USA

[18] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA USA

[19] Baylor Coll Med, Dept Pediat, Div Hematol Oncol, Houston, TX USA

[20] UCL, Inst Clin Trials & Methodol, London, England

[21] Med Univ South Carolina, Med Univ South Carolina Digest Dis Res Ctr, Charleston, SC USA

[22] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA USA

[23] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Dept Med, Toronto, ON, Canada

[24] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[25] Univ Michigan, Med Sch, Dept Pediat, Ann Arbor, MI USA

[26] McMaster Univ, Michael G DeGroote Ctr Transfus Res, Dept Med, Hamilton, ON, Canada

[27] Canadian Blood Serv, Hamilton, ON, Canada

来源：

LANCET HAEMATOLOGY | 2025年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

RANDOMIZED CONTROLLED-TRIAL; ANEMIA; SUPPLEMENTATION; ABSORPTION; SULFATE; ISOMALTOSIDE; METAANALYSIS; THERAPY; DISEASE;

D O I：

10.1016/S2352-3026(25)00038-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Iron deficiency is the most common micronutrient deficiency worldwide. Oral iron is often recommended as first-line treatment, but there is no consensus on the optimal formulation, dosing strategy, or which patients should be treated preferentially with intravenous iron. To address these challenges, the Iron Consortium at Oregon Health & Science University (OHSU) convened an international panel of 26 experts in haematology, primary care, paediatrics, obstetrics, gastroenterology, cancer, and patient advocacy among its members. This panel was supplemented by insights from a four-person patient focus group to develop current recommendations using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The panel developed clinically relevant questions in five priority topic areas, a systematic literature search was performed, and studies meeting a priori criteria were included to generate evidence tables for recommendation development. Evidence-based and expert opinion-based recommendations were made through a structured anonymous consensus voting process at an in-person meeting in Portland, OR, USA, hosted by OHSU on Feb 16-17, 2024. The expert panel made seven evidence-based recommendations for three demographic groups with iron deficiency: non-pregnant adults, pregnant individuals, and infants, children, and adolescents. Expert opinions supported the recommendations on 21 aspects of care for which there is insufficient evidence. This Review provides evidence-based recommendations and expert consensus on the diagnosis, treatment, and management of iron deficiency, detailing best practices for oral and intravenous iron repletion across diverse patient populations.

引用

页码：e376 / e388

页数：13

共 55 条

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