Non-coding RNAs in adipose-derived stem cell exosomes: Mechanisms, therapeutic potential, and challenges in wound healing

被引：1
作者：
Rong, Jian [1 ,2 ]
Li, Yao-Yao [1 ,2 ]
Wang, Xin [1 ,2 ]
Wang, Jia-Ning [1 ,2 ]
Song, Mei [1 ,2 ]
机构：
[1] 940th Hosp Joint Logist Support Force Chinese Peop, Dept Burns & Plast Surg, 333 Nanbin Rd, Lanzhou 730050, Gansu, Peoples R China
[2] 940th Hosp Joint Logist Support Force Chinese Peop, Dept Plateau Med, Lanzhou 730050, Gansu, Peoples R China
来源：
WORLD JOURNAL OF STEM CELLS | 2025年 / 17卷 / 04期
关键词：
Adipose-derived stem cell exosomes; Wound healing; MicroRNAs; Long non-coding RNAs; Circular RNAs; MACROPHAGES; MIGRATION; OUTCOMES;
D O I：
10.4252/wjsc.v17.i4.102917
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The treatment of complex wounds presents a significant clinical challenge due to the limited availability of standardized therapeutic options. Adipose-derived stem cell exosomes (ADSC-Exos) are promising for their capabilities to enhance angiogenesis, mitigate oxidative stress, modulate inflammatory pathways, support skin cell regeneration, and promote epithelialization. These exosomes deliver non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, which facilitate collagen remodeling, reduce scar formation, and expedite wound healing. This study reviews the mechanisms, therapeutic roles, and challenges of non-coding RNA-loaded ADSC-Exos in wound healing and identifies critical directions for future research. It aims to provide insights for researchers into the potential mechanisms and clinical applications of ADSC-Exos non-coding RNAs in wound healing.
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页数：15
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