Non-coding RNAs in adipose-derived stem cell exosomes: Mechanisms, therapeutic potential, and challenges in wound healing

被引：1
作者：
Rong, Jian [1 ,2 ]
Li, Yao-Yao [1 ,2 ]
Wang, Xin [1 ,2 ]
Wang, Jia-Ning [1 ,2 ]
Song, Mei [1 ,2 ]
机构：
[1] 940th Hosp Joint Logist Support Force Chinese Peop, Dept Burns & Plast Surg, 333 Nanbin Rd, Lanzhou 730050, Gansu, Peoples R China
[2] 940th Hosp Joint Logist Support Force Chinese Peop, Dept Plateau Med, Lanzhou 730050, Gansu, Peoples R China
来源：
WORLD JOURNAL OF STEM CELLS | 2025年 / 17卷 / 04期
关键词：
Adipose-derived stem cell exosomes; Wound healing; MicroRNAs; Long non-coding RNAs; Circular RNAs; MACROPHAGES; MIGRATION; OUTCOMES;
D O I：
10.4252/wjsc.v17.i4.102917
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The treatment of complex wounds presents a significant clinical challenge due to the limited availability of standardized therapeutic options. Adipose-derived stem cell exosomes (ADSC-Exos) are promising for their capabilities to enhance angiogenesis, mitigate oxidative stress, modulate inflammatory pathways, support skin cell regeneration, and promote epithelialization. These exosomes deliver non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, which facilitate collagen remodeling, reduce scar formation, and expedite wound healing. This study reviews the mechanisms, therapeutic roles, and challenges of non-coding RNA-loaded ADSC-Exos in wound healing and identifies critical directions for future research. It aims to provide insights for researchers into the potential mechanisms and clinical applications of ADSC-Exos non-coding RNAs in wound healing.
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页数：15
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[1]   Exosomes of Adipose Tissue-Derived Stem Cells Promote Wound Healing by Sponging miR-17-5p and Inducing Autophagy Protein Ulk1 [J].
An, Yang ;
Huang, Fei ;
Tan, Xiaojie ;
Zhu, Shiou ;
Zhen, Yonghuan ;
Shang, Yujia ;
Ding, Pengbing ;
Li, Dong ;
Wu, Junhao .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2023, 151 (05) :1016-1028
[2]   Diabetic Foot Ulcers A Review [J].
Armstrong, David G. ;
Tan, Tze-Woei ;
Boulton, Andrew J. M. ;
Bus, Sicco A. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2023, 330 (01) :62-75
[3]   Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer [J].
Armstrong, David G. ;
Swerdlow, Mark A. ;
Armstrong, Alexandria A. ;
Conte, Michael S. ;
Padula, William V. ;
Bus, Sicco A. .
JOURNAL OF FOOT AND ANKLE RESEARCH, 2020, 13 (01)
[4]   Isolation of Exosomes from Blood Plasma: Qualitative and Quantitative Comparison of Ultracentrifugation and Size Exclusion Chromatography Methods [J].
Baranyai, Tamas ;
Herczeg, Kata ;
Onodi, Zsofia ;
Voszka, Istvan ;
Modos, Karoly ;
Marton, Nikolett ;
Nagy, Gyoergy ;
Maeger, Imre ;
Wood, Matthew J. ;
El Andaloussi, Samir ;
Palinkas, Zoltan ;
Kumar, Vikas ;
Nagy, Pater ;
Kittel, Agnes ;
Buzas, Edit Iren ;
Ferdinandy, Peter ;
Giricz, Zoltan .
PLOS ONE, 2015, 10 (12)
[5]   PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties [J].
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Derudas, Bruno ;
Rigamonti, Elena ;
Dievart, Rebecca ;
Brozek, John ;
Haulon, Stephan ;
Zawadzki, Christophe ;
Jude, Brigitte ;
Torpier, Gerard ;
Marx, Nikolaus ;
Staels, Bart ;
Chinetti-Gbaguidi, Giulia .
CELL METABOLISM, 2007, 6 (02) :137-143
[6]   Circular RNA mmu_circ_0001295 from hypoxia pretreated adipose-derived mesenchymal stem cells (ADSCs) exosomes improves outcomes and inhibits sepsis-induced renal injury in a mouse model of sepsis [J].
Cao, Shan ;
Huang, Ying ;
Dai, Zhenzhao ;
Liao, Yang ;
Zhang, Jinfeng ;
Wang, Lingli ;
Hao, Zhiyan ;
Wang, Fei ;
Wang, Dan ;
Liu, Lixiao .
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Dorado, Gabriel .
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Chang, Huanchao ;
Chen, Junliang ;
Ding, Kun ;
Cheng, Tianling ;
Tang, Shengjian .
ADIPOCYTE, 2023, 12 (01)
[9]   Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation [J].
Chao, Julie ;
Guo, Youming ;
Chao, Lee .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
[10]   Exosomes Derived from Adipose Stem Cells Enhance Angiogenesis in Diabetic Wound Via miR-146a-5p/JAZF1 Axis [J].
Che, Dehui ;
Xiang, Xinjian ;
Xie, Juan ;
Chen, Zenghong ;
Bao, Qiong ;
Cao, Dongsheng .
STEM CELL REVIEWS AND REPORTS, 2024, 20 (04) :1026-1039
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