Brexucabtagene Autoleucel versus Allogeneic Hematopoietic Cell Transplantation in Relapsed and Refractory Mantle Cell Lymphoma

被引：2

作者：

Liebers, Nora ^{[1
,2
,3
,4
,5
]}

Boumendil, Ariane ^{[6
]}

Finel, Herve ^{[6
]}

Edelmann, Dominic ^{[7
]}

Kobbe, Guido ^{[1
,4
]}

Baermann, Ben-Niklas ^{[1
,4
]}

Serroukh, Yasmina ^{[8
]}

Blaise, Didier ^{[9
]}

Beelen, Dietrich Wilhelm ^{[10
]}

Solano, Carlos ^{[11
]}

Itaelae-Remes, Maija ^{[12
]}

van Meerten, Tom ^{[13
]}

Choi, Goda ^{[13
]}

Schmidt, Susanne Anna Christine ^{[1
,4
]}

Kroeger, Nicolaus ^{[14
]}

Byrne, Jenny ^{[15
]}

Tudesq, Jean-Jacques ^{[16
]}

Ossami Saidy, Anna ^{[17
]}

Nunes, Ana ^{[18
]}

Siddiqi, Rubina ^{[18
]}

Baro, Elande ^{[18
]}

Zheng, Dan ^{[18
]}

Kloos, Ioana ^{[18
]}

Dreger, Peter ^{[5
,6
]}

Sureda, Anna ^{[6
,19
]}

Glass, Bertram ^{[6
,17
]}

Dietrich, Sascha ^{[1
,4
,5
,6
]}

机构：

[1] Univ Hosp Duesseldorf, Dept Hematol Oncol & Clin Immunol, Moorenstr 5, D-40225 Dusseldorf, Germany

[2] Natl Ctr Tumor Dis NCT Heidelberg, Dept Translat Med Oncol, Heidelberg, Germany

[3] German Canc Res Ctr, Heidelberg, Germany

[4] Ctr Integrated Oncol Aachen Bonn Cologne Dusseldor, Cologne, Germany

[5] Heidelberg Univ Hosp, Dept Internal Med 5, Heidelberg, Germany

[6] European Soc Blood & Marrow Transplantat, Lymphoma Working Party, Paris, France

[7] German Canc Res Ctr, Div Biostat, Heidelberg, Germany

[8] Erasmus MC, Univ Med Ctr Rotterdam, Dept Hematol, Canc Inst, Rotterdam, Netherlands

[9] Inst Paoli Calmettes, Marseille, France

[10] Univ Hosp Essen, Essen, Germany

[11] Univ Valencia, Hosp Clin Univ INCLIVA, Valencia, Spain

[12] Univ Hosp Turku, Turku, Finland

[13] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands

[14] Univ Med Ctr Hamburg, Hamburg, Germany

[15] Univ Nottingham, Nottingham, England

[16] CHU Lapeyronie, Montpellier, France

[17] HELIOS Klinikum Berlin Buch, Dept Hematol, Berlin, Germany

[18] Kite, Gilead Co, Santa Monica, CA USA

[19] Univ Barcelona, Inst Catala Oncol LHospitalet, Clin Hematol Dept, IDIBELL, Barcelona, Spain

来源：

BLOOD CANCER DISCOVERY | 2025年 / 6卷 / 03期

关键词：

INTERNATIONAL BLOOD; THERAPY; DISEASE; TUMORS;

D O I：

10.1158/2643-3230.BCD-24-0178

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brexucabtagene autoleucel (brexu-cel) and allogeneic hematopoietic cell transplantation (alloHCT) are effective treatments for relapsed and refractory mantle cell lymphoma (r/r MCL), but the optimal choice remains unclear. We conducted an analysis of 64 patients aged >= 50 years with r/r MCL treated with brexu-cel in the ZUMA-2 study, matching them 1:1 by propensity score to 64 (of 272) patients with r/r MCL who underwent alloHCT using data from the European Society for Blood and Marrow Transplantation registry. The median follow-up time was 36.5 months for the brexu-cel cohort and 34.1 months for the matched alloHCT cohort. Patients who received brexu-cel had a significantly higher overall survival [(OS) 81.3% vs. 59.2%; HR, 0.39; P = 0.004] and lower nonrelapse mortality (3.6% vs. 21.2%; P = 0.015) 1 year after treatment. Chronic GVHD occurred within the first year in 26.9% of patients who underwent alloHCT. However, long-term progression-free survival (PFS) and OS remain comparable. Despite the limitations of this nonrandomized study, the findings indicate a superior safety profile for brexu-cel in r/r MCL.Significance: Patients aged >= 50 years with r/r MCL had superior OS and lower nonrelapse mortality 1 year after receiving brexu-cel compared with alloHCT. However, the long-term PFS and OS are similar for both treatments. Individual risk-benefit evaluation is essential to guide optimal treatment decisions.

引用

页码：182 / 190

页数：9

共 21 条

[1] The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms [J].

Alaggio, Rita ;

Amador, Catalina ;

Anagnostopoulos, Ioannis ;

Attygalle, Ayoma D. ;

Araujo, Iguaracyra Barreto de Oliveira ;

Berti, Emilio ;

Bhagat, Govind ;

Borges, Anita Maria ;

Boyer, Daniel ;

Calaminici, Mariarita ;

Chadburn, Amy ;

Chan, John K. C. ;

Cheuk, Wah ;

Chng, Wee-Joo ;

Choi, John K. ;

Chuang, Shih-Sung ;

Coupland, Sarah E. ;

Czader, Magdalena ;

Dave, Sandeep S. ;

de Jong, Daphne ;

Du, Ming-Qing ;

Elenitoba-Johnson, Kojo S. ;

Ferry, Judith ;

Geyer, Julia ;

Gratzinger, Dita ;

Guitart, Joan ;

Gujral, Sumeet ;

Harris, Marian ;

Harrison, Christine J. ;

Hartmann, Sylvia ;

Hochhaus, Andreas ;

Jansen, Patty M. ;

Karube, Kennosuke ;

Kempf, Werner ;

Khoury, Joseph ;

Kimura, Hiroshi ;

Klapper, Wolfram ;

Kovach, Alexandra E. ;

Kumar, Shaji ;

Lazar, Alexander J. ;

Lazzi, Stefano ;

Leoncini, Lorenzo ;

Leung, Nelson ;

Leventaki, Vasiliki ;

Li, Xiao-Qiu ;

Lim, Megan S. ;

Liu, Wei-Ping ;

Louissaint, Abner, Jr. ;

Marcogliese, Andrea ;

Medeiros, L. Jeffrey .

LEUKEMIA, 2022, 36 (07) :1720-1748

[2] Defining the Intensity of Conditioning Regimens: Working Definitions [J].

Bacigalupo, Andrea ;

Ballen, Karen ;

Rizzo, Doug ;

Giralt, Sergio ;

Lazarus, Hillard ;

Ho, Vincent ;

Apperley, Jane ;

Slavin, Shimon ;

Pasquini, Marcelo ;

Sandmaier, Brenda M. ;

Barrett, John ;

Blaise, Didier ;

Lowski, Robert ;

Horowitz, Mary .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (12) :1628-1633

[3] Post-Transplantation CyclophosphamideBased Graft-versus-Host Disease Prophylaxis [J].

Bolanos-Meade, J. ;

Hamadani, M. ;

Wu, J. ;

Al Malki, M. M. ;

Martens, M. J. ;

Runaas, L. ;

Elmariah, H. ;

Rezvani, A. R. ;

Gooptu, M. ;

Larkin, K. T. ;

Shaffer, B. C. ;

El Jurdi, N. ;

Loren, A. W. ;

Solh, M. ;

Hall, A. C. ;

Alousi, A. M. ;

Jamy, O. H. ;

Perales, M. -A. ;

Yao, J. M. ;

Applegate, K. ;

Bhatt, A. S. ;

Kean, L. S. ;

Efebera, Y. A. ;

Reshef, R. ;

Clark, W. ;

DiFronzo, N. L. ;

Leifer, E. ;

Horowitz, M. M. ;

Jones, R. J. ;

Holtan, S. G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2023, 388 (25) :2338-2348

[4] A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy [J].

dos Santos, David M. Cordas ;

Tix, Tobias ;

Shouval, Roni ;

Gafter-Gvili, Anat ;

Alberge, Jean-Baptiste ;

Cliff, Edward R. Scheffer ;

Theurich, Sebastian ;

von Bergwelt-Baildon, Michael ;

Ghobrial, Irene M. ;

Subklewe, Marion ;

Perales, Miguel-Angel ;

Rejeski, Kai .

NATURE MEDICINE, 2024, 30 (09) :2667-2678

[5] T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy [J].

Ghilardi, Guido ;

Fraietta, Joseph A. ;

Gerson, James N. ;

Van Deerlin, Vivianna M. ;

Morrissette, Jennifer J. D. ;

Caponetti, Gabriel C. ;

Paruzzo, Luca ;

Harris, Jaryse C. ;

Chong, Elise A. ;

Adaniya, Sandra P. Susanibar ;

Svoboda, Jakub ;

Nasta, Sunita D. ;

Ugwuanyi, Ositadimma H. ;

Landsburg, Daniel J. ;

Fardella, Eugenio ;

Waxman, Adam J. ;

Chong, Emeline R. ;

Patel, Vrutti ;

Pajarillo, Raymone ;

Kulikovskaya, Irina ;

Lieberman, David B. ;

Cohen, Adam D. ;

Levine, Bruce L. ;

Stadtmauer, Edward A. ;

Frey, Noelle V. ;

Vogl, Dan T. ;

Hexner, Elizabeth O. ;

Barta, Stefan K. ;

Porter, David L. ;

Garfall, Alfred L. ;

Schuster, Stephen J. ;

June, Carl H. ;

Ruella, Marco .

NATURE MEDICINE, 2024, 30 (04) :984-989

[6] Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies: The GETH/GELTAMO Experience [J].

Gutierrez, Antonio ;

Bento, Leyre ;

Novelli, Silvana ;

Martin, Alejandro ;

Gutierrez, Gonzalo ;

Salas, Maria Queralt ;

Bastos-Oreiro, Mariana ;

Perez, Ariadna ;

Hernani, Rafael ;

Viguria, Maria Cruz ;

Lopez-Godino, Oriana ;

Montoro, Juan ;

Pinana, Jose ;

Ferra, Christelle ;

Parody, Rocio ;

Martin, Carmen ;

Espanol, Ignacio ;

Yanez, Lucrecia ;

Rodriguez, Guillermo ;

Zanabili, Joud ;

Herrera, Pilar ;

Varela, Maria ;

Sampol, Antonia ;

Solano, Carlos ;

Caballero, Dolores .

CANCERS, 2022, 14 (11)

[7] Allogeneic Hematopoietic Cell Transplantation for Chemotherapy-Unresponsive Mantle Cell Lymphoma: A Cohort Analysis from the Center for International Blood and Marrow Transplant Research [J].

Hamadani, Mehdi ;

Saber, Wael ;

Ahn, Kwang Woo ;

Carreras, Jeanette ;

Cairo, Mitchell S. ;

Fenske, Timothy S. ;

Gale, Robert Peter ;

Gibson, John ;

Hale, Gregory A. ;

Hari, Parameswaran N. ;

Hsu, Jack W. ;

Inwards, David J. ;

Kamble, Rammurti T. ;

Klein, Anderas ;

Maharaj, Dipnarine ;

Marks, David I. ;

Rizzieri, David A. ;

Savani, Bipin N. ;

Schouten, Harry C. ;

Waller, Edmund K. ;

Wirk, Baldeep ;

Lazarus, Hillard M. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2013, 19 (04) :625-631

[8] Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy [J].

Hamilton, Mark P. ;

Sugio, Takeshi ;

Noordenbos, Troy ;

Shi, Shuyu ;

Bulterys, Philip L. ;

Liu, Chih Long ;

Kang, Xiaoman ;

Olsen, Mari N. ;

Good, Zinaida ;

Dahiya, Saurabh ;

Frank, Matthew J. ;

Sahaf, Bita ;

Mackall, Crystal L. ;

Gratzinger, Dita ;

Diehn, Maximilian ;

Alizadeh, Ash A. ;

Miklos, David B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2024, 390 (22) :2047-2060

[9] CAR T-cell therapy versus allogeneic HSCT for relapsed or refractory mantle cell lymphoma [J].

Iacoboni, Gloria ;

Dietrich, Sascha ;

Liebers, Nora .

LANCET HAEMATOLOGY, 2023, 10 (12) :E951-E952

[10] American Society of Transplantation and Cellular Therapy, Center of International Blood and Marrow Transplant Research, and European Society for Blood and Marrow Transplantation Clinical Practice Recommendations for Transplantation and Cellular Therapies in Mantle Cell Lymphoma [J].

Munshi, Pashna N. ;

Hamadani, Mehdi ;

Kumar, Ambuj ;

Dreger, Peter ;

Friedberg, Jonathan W. ;

Dreyling, Martin ;

Kahl, Brad ;

Jerkeman, Mats ;

Kharfan-Dabaja, Mohamed A. ;

Locke, Frederick L. ;

Shadman, Mazyar ;

Hill, Brian T. ;

Ahmed, Sairah ;

Herrera, Alex F. ;

Sauter, Craig S. ;

Bachanova, Veronika ;

Ghosh, Nilanjan ;

Lunning, Matthew ;

Kenkre, Vaishalee P. ;

Aljurf, Mahmoud ;

Wang, Michael ;

Maddocks, Kami J. ;

Leonard, John P. ;

Kamdar, Manali ;

Phillips, Tycel ;

Cashen, Amanda F. ;

Inwards, David J. ;

Sureda, Anna ;

Cohen, Jonathon B. ;

Smith, Sonali M. ;

Carlo-Stella, Carmello ;

Savani, Bipin ;

Robinson, Stephen P. ;

Fenske, Timothy S. .

TRANSPLANTATION AND CELLULAR THERAPY, 2021, 27 (09) :720-728

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