Copper-Catalyzed Sulfonamidation of N,N-Dimethyl Formamide via C(sp3)―H Bond Functionalization

被引：0

作者：

Ramani, Arti ^{[1
]}

Begari, Eeshwaraiah ^{[2
]}

Naveen, Togati ^{[1
]}

机构：

[1] Sardar Vallabhbhai Natl Inst Technol, Dept Chem, Surat 395007, Gujarat, India

[2] Cent Univ Gujarat, Sch Appl Mat Sci, Gandhinagar 382030, India

来源：

CHEMISTRYSELECT | 2025年 / 10卷 / 25期

关键词：

C & horbar; H bond functionalization; Copper salt; Formamidomethylation; Sulfonamides; SP(3) C-H; DEHYDROGENATIVE COUPLING REACTIONS; TRANSITION-METAL; INHIBITOR; ADJACENT; ETHERS; AZOLES; POTENT; AMIDES;

D O I：

10.1002/slct.202501889

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a novel strategy for the direct sulfonamidation of N,N-dimethyl formamide through a copper-catalyzed C(sp3)& horbar;H functionalization reaction. This method represents a significant advancement in the field, as it does not require any exogenous acid or base, and the reaction can be completed within 2 h. A variety of N-formamidomethylated sulfonamides were synthesized in moderate to high yields. Hitherto, no prior reports have been found in the literature for the sulfonamidation of N,N-dimethyl formamide, making this reaction an important breakthrough in synthetic organic chemistry.

引用

页数：5

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