Phenol as a breath marker for hemodialysis of chronic kidney disease patients

被引：0
作者：
Eickel, Isabell [1 ]
Zygmunt, Anne-Christine [1 ]
Streit, Frank [2 ]
Tampe, Bjoern [3 ]
Kunze-Szikszay, Nils [4 ]
Perl, Thorsten [1 ]
机构：
[1] Univ Med Ctr Gottingen, Dept Gen Visceral & Pediat Surg, Gottingen, Germany
[2] Univ Med Ctr Gottingen, Dept Clin Chem, Gottingen, Germany
[3] Univ Med Ctr Gottingen, Dept Nephrol & Rheumatol, Gottingen, Germany
[4] Univ Med Ctr Gottingen, Dept Anesthesiol, Gottingen, Germany
来源：
JOURNAL OF BREATH RESEARCH | 2025年 / 19卷 / 03期
关键词：
chronic kidney disease; breath analysis; breath marker; ion mobility spectrometry; MCC-IMS; phenol; P-CRESOL SULFATE; UREMIC TOXINS; RENAL-FAILURE; SPECTROMETRY; PLASMA; FECES; SERUM; ACID;
D O I：
10.1088/1752-7163/add958
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We aimed to identify biomarkers in breath analysis with multicapillary column-ion mobility spectrometry (MCC-IMS) to monitor the haemodialysis for chronic kidney disease (CKD) patients fast and non-invasive. Six patients' breath was analyzed via MCC-IMS before and after dialysis and compared to blood plasma samples analyzed via ultra performance liquid chromatography-fluorescence detector for potential renal failure biomarkers. Additionally, breath from six healthy control persons was analyzed. Phenol was found as a breath marker for CKD. For three patients the phenol concentration in breath and plasma was elevated before and decreased during dialysis and reached values in the range of healthy control persons. The peak-intensity of phenol-monomer peaks of P01-P04 was reduced from an average of 16.58 (5.42-27.28) a.U. to 7.03 (0.00-13.65) a.U., which is a reduction by 42.51 (-10.55-100.00) %. The control group has an average peak-intensity of 8.50 (5.00-12.00) a.U. This study shows that the measurement of phenol via breath analysis could be used to monitor the haemodialysis for CKD-patients and might also be usable for the calculation of haemodialysis dose in the future.The study is registered in the German Clinical Trials Register under number DRKS00029679.
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相关论文
共 39 条
[1]   A robust, accurate, sensitive LC-MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells [J].
Ahmed, Sabbir ;
Sparidans, Rolf W. ;
Lu, Jingyi ;
Mihaila, Silvia M. ;
Gerritsen, Karin G. F. ;
Masereeuw, Rosalinde .
BIOMEDICAL CHROMATOGRAPHY, 2022, 36 (05)
[2]   Cytotoxic Effects of p-Cresol in Renal Epithelial Tubular Cells [J].
Brocca, Alessandra ;
Virzi, Grazia Maria ;
de Cal, Massimo ;
Cantaluppi, Vincenzo ;
Ronco, Claudio .
BLOOD PURIFICATION, 2013, 36 (3-4) :219-225
[3]  
COAN ML, 1982, RES COMMUN CHEM PATH, V36, P229
[4]   Quantification of p-cresol sulphate in human plasma by selected reaction monitoring [J].
Cuoghi, Aurora ;
Caiazzo, Marialuisa ;
Bellei, Elisa ;
Monari, Emanuela ;
Bergamini, Stefania ;
Palladino, Giuseppe ;
Ozben, Tomris ;
Tomasi, Aldo .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 404 (6-7) :2097-2104
[5]   Kt/V (and especially its modifications) remains a useful measure of hemodialysis dose [J].
Daugirdas, John T. .
KIDNEY INTERNATIONAL, 2015, 88 (03) :466-473
[6]   THE RENAL EFFECTS OF SODIUM CYANATE IN RATS [J].
DICKER, SE .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1950, 5 (01) :13-20
[7]  
Dobrek Lukasz, 2022, Pol Merkur Lekarski, V50, P323
[8]   GC-IMS headspace analyses allow early recognition of bacterial growth and rapid pathogen differentiation in standard blood cultures [J].
Drees, Carolin ;
Vautz, Wolfgang ;
Liedtke, Sascha ;
Rosin, Christopher ;
Althoff, Kirsten ;
Lippmann, Martin ;
Zimmermann, Stefan ;
Legler, Tobias J. ;
Yildiz, Duygu ;
Perl, Thorsten ;
Kunze-Szikszay, Nils .
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 103 (21-22) :9091-9101
[9]   Normal and Pathologic Concentrations of Uremic Toxins [J].
Duranton, Flore ;
Cohen, Gerald ;
De Smet, Rita ;
Rodriguez, Mariano ;
Jankowski, Joachim ;
Vanholder, Raymond ;
Argiles, Angel .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2012, 23 (07) :1258-1270
[10]   Uremic toxins originating from colonic microbial metabolism [J].
Evenepoel, Pieter ;
Meijers, Bjorn K. I. ;
Bammens, Bert R. M. ;
Verbeke, Kristin .
KIDNEY INTERNATIONAL, 2009, 76 :S12-S19
1234