The Application of Stem Cells and Exosomes in Promoting Nerve Conduits for Peripheral Nerve Repair

被引：0
作者：
Li, Mengen [1 ,2 ,3 ,4 ]
Tang, Ye [1 ,2 ,3 ,4 ]
Zhou, Chengkai [1 ,2 ,3 ]
Geng, Yan [1 ,2 ,3 ]
Zhang, Chenxi [1 ,2 ,3 ]
Hsu, Yuwei [1 ,2 ,3 ,5 ]
Ma, Le [1 ,2 ,3 ]
Guo, Wei [5 ]
Li, Ming [1 ,2 ,3 ]
Wang, Yanhua [1 ,2 ,4 ]
机构：
[1] Natl Ctr Trauma Med, Beijing 100044, Peoples R China
[2] Peking Univ, Key Lab Trauma & Neural Regenerat, Minist Educ, Beijing 100044, Peoples R China
[3] Peking Univ Peoples Hosp, Trauma Med Ctr, Beijing 100044, Peoples R China
[4] Peking Univ Peoples Hosp, Dept Orthoped & Trauma, Beijing 100044, Peoples R China
[5] Peking Univ Peoples Hosp, Emergency Dept, Beijing 100044, Peoples R China
来源：
BIOMATERIALS RESEARCH | 2025年 / 29卷
基金：
国家重点研发计划; 北京市自然科学基金;
关键词：
EXTRACELLULAR VESICLES; NEURAL DIFFERENTIATION; NEUROTROPHIC FACTOR; SCHWANN-CELLS; NEURONAL DIFFERENTIATION; REGENERATION; ACTIVATION; EXPRESSION; SECRETION; SPHEROIDS;
D O I：
10.34133/bmr.0160
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The repair of peripheral nerve injury (PNI) presents a multifaceted and protracted challenge, with current therapeutic approaches failing to achieve optimal repair outcomes, thereby not satisfying the considerable clinical demand. The advent of tissue engineering has led to a growing body of experimental evidence indicating that the synergistic application of nerve conduits, which provide structural guidance, alongside the biological signals derived from exosomes and stem cells, yields superior therapeutic results for PNI compared to isolated interventions. This combined approach holds great promise for clinical application. In this review, we present the latest advancements in the treatment of PNI through the integration of stem cells or exosomes with nerve conduits. We have addressed the inadequate efficiency of exosomes or stem cells in conjunction with nerve conduits from 3 perspectives: enhancing stem cells or exosomes, improving nerve conduits, and incorporating physical stimulation.
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页数：26
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