Malignant gastrointestinal neuroectodermal tumor: A report of 2 cases and a review of the literature

Malignant gastrointestinal neuroectodermal tumour (GNET) is an extremely rare neoplasm first described by Zambrano in 2003 as clear cell sarcoma like tumor of the gastrointestinal tract. In contrast to clear cell sarcoma, it has giant osteoclast cells and shows diffuse and intense positivity for S-100 with no immunohistochemical or ultrastructural melanocyte differentiation. We present the first cases of GNET reported in South America, occurring in Peru. Two cases of GNET, one in a female and one in a male, both between 60 and 70 years of age, were referred our hospital for reevaluation. One underwent further treatment in our centre, but with an unfavourable evolution. Pathologists should be aware of the diagnostic criteria for GNET in order avoid misdiagnosis due to confusion with other non-epithelial gastrointestinal neoplasms. 2020 Sociedad Espanola de Anatom<acute accent>& imath;a Patolo<acute accent>gica. Published by Elsevier Espana, S.L.U. All rights reserved.