RIFM fragrance ingredient safety assessment, 1-octanol, CAS registry number 111-87-5

被引：1

作者：

Api, A. M. ^{[1
]}

Bartlett, A. ^{[1
]}

Belsito, D. ^{[2
]}

Botelho, D. ^{[1
]}

Bruze, M. ^{[3
]}

Bryant-Friedrich, A. ^{[4
]}

Burton, G. A. ^{[5
]}

Cancellieri, M. A. ^{[1
]}

Chon, H. ^{[1
]}

Cronin, M. ^{[6
]}

Crotty, S. ^{[1
]}

Dagli, M. L. ^{[7
]}

Dekant, W. ^{[8
]}

Deodhar, C. ^{[1
]}

Farrell, K. ^{[1
]}

Fryer, A. D. ^{[9
]}

Jones, L. ^{[1
]}

Joshi, K. ^{[1
]}

Lapczynski, A. ^{[1
]}

Laskin, D. L. ^{[10
]}

Lavelle, M. ^{[1
]}

Lee, I. ^{[1
]}

Moustakas, H. ^{[1
]}

Muldoon, J. ^{[1
]}

Penning, T. M. ^{[11
]}

Piersma, A. H. ^{[12
]}

Ritacco, G. ^{[1
]}

Sadekar, N. ^{[1
]}

Schember, I. ^{[1
]}

Schultz, T. W. ^{[11
]}

Siddiqi, F. ^{[1
]}

Sipesm, I. G. ^{[13
]}

Sullivan, G. ^{[1
]}

Thakkar, Y. ^{[1
]}

机构：

[1] Res Inst Fragrance Mat Inc, 1200 MacArthur Blvd, Suite 306, Mahwah, NJ 07430 USA

[2] Columbia Univ, Med Ctr, Dept Dermatol, Member Expert Panel Fragrance Safety, 161 Ft Washington Ave, New York, NY 10032 USA

[3] Malmo Univ Hosp, Dept Occupat & Environm Dermatol, Member Expert Panel Fragrance Safety, Sodra Forstadsgatan 101,Entrance 47, SE-20502 Malmo, Sweden

[4] Wayne State Univ, Member Expert Panel Fragrance Safety, Pharmaceut Sci, 42 W Warren Ave, Detroit, MI 48202 USA

[5] Univ Michigan, Sch Nat Resources & Environm, Member Expert Panel Fragrance Safety, Dana Bldg G110,440 Church St, Ann Arbor, MI 58109 USA

[6] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Member Expert Panel Fragrance Safety, Liverpool, England

[7] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Member Expert Panel Fragrance Safety, Av Prof Dr Orlando Marques Paiva 87, BR-05508900 Sao Paulo, Brazil

[8] Univ Wurzburg, Dept Toxicol, Member Expert Panel Fragrance Safety, Versbacher Str 9, D-97078 Wurzburg, Germany

[9] Oregon Hlth & Sci Univ, Member Expert Panel Fragrance Safety, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[10] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmacol & Toxicol, Member Expert Panel Fragrance Safety, 160 Frelinghuysen Rd, Piscataway, NJ 08854 USA

[11] Univ Penn, Ctr Excellencein Environm Toxicol, Perelman Sch Med, Member Expert Panel Fragrance Safety, 1316 Biomed Res Bldg BRB II-III,421 Curie Blvd, Philadelphia, PA 19104 USA

[12] Univ Utrecht, Inst Risk Assessment Sci IRAS, Member Expert Panel Fragrance Safety, Utrecht, Netherlands

[13] Univ Arizona, Coll Med, Dept Pharmacol, Member Expert Panel Fragrance Safety, 1501 North Campbell Av,POB 245050, Tucson, AZ 85724 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2025年 / 201卷

关键词：

3 CONTINENTAL SITES; PERSONAL CARE; CONSUMER EXPOSURE; MODEL; TOXICITY; ABSORPTION; PREDICTION; THRESHOLD; COSMETICS; ASSAY;

D O I：

10.1016/j.fct.2025.115465

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

1-Octanol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from 1-octanol and read-across analog heptyl alcohol (CAS # 111-70-6) show that 1-octanol is not expected to be genotoxic. Data on read-across analog heptyl alcohol (CAS # 111-70-6) provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and fertility endpoints. Data on 1-octanol provide a calculated MOE >100 for the developmental toxicity endpoint. Data from read-across analog 1-decanol (CAS # 112-30-1) provided 1-octanol a No Expected Sensitization Induction Level (NESIL) of 10000 mu g/cm2 for the skin sensitization endpoint. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 1-octanol is not expected to be photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 1-octanol is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 1-octanol was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

引用

页数：11

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