Pyrazole-Sulfone hybridization via silver-catalyzed regioselective aza-Michael addition of pyrazoles to vinyl sulfones: Synthesis of N-sulfonylethylated pyrazoles

被引：0

作者：

Zhang, Xue ^{[1
]}

Song, Yang ^{[3
]}

Peng, Yutong ^{[1
]}

Zhu, Dakang ^{[1
]}

Zhang, Wanxin ^{[1
]}

Yu, Haifeng ^{[1
,2
]}

Zhao, Xiaobo ^{[1
,2
]}

机构：

[1] Baicheng Normal Univ, Coll Chem, Baicheng, Jilin, Peoples R China

[2] Baicheng Normal Univ, Key Lab Clean Energy Western Jilin Prov, Baicheng, Jilin, Peoples R China

[3] Liaoning Coning Testing Co Ltd, Lab Testing, Shenyang, Liaoning, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2025年 / 55卷 / 13期

关键词：

Pyrazoles; Vinyl sulfones; Regioselectivity; aza-Michael addition; ANTICANCER; SULFONYLPYRAZOLES; DISCOVERY; ANALOGS; DESIGN; ACCESS; KINASE;

D O I：

10.1080/00397911.2025.2518387

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this research, the facile pyrazole-sulfone hybridization via Ag2CO3-catalyzed aza-Michael addition of pyrazoles to vinyl sulfones has been developed. The methodology offers an efficient and regioselective synthesis of N-sulfonylethylated pyrazoles as an important subset of pyrazole-sulfone hybrids and it featured mild reaction conditions, excellent yields and high regioselectivity (reaching the highest N1/N2 ratio of 25:1).

引用

页码：985 / 995

页数：11

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