Effect of Proton Pump Inhibitor on Quality of Life of Patients with Laryngopharyngeal Reflux

被引：0

作者：

Bhatt, Kriti ^{[1
]}

Krishna Gupta, Rajeev ^{[1
]}

Bhargava, Anuja ^{[1
]}

Faiz, S. M. ^{[1
]}

Srivastava, Saurabh ^{[1
]}

Dutta, Eshani ^{[1
]}

Khalid, Abdul ^{[1
]}

机构：

[1] Eras Lucknow Med Coll & Hosp, Dept Otorhinolarngol & Head & Neck Surg, Lucknow, India

来源：

INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY | 2025年

关键词：

Laryngopharyngeal Reflux; Proton-pump Inhibitor; Quality of Life; SYMPTOM INDEX; DISEASE; RELIABILITY; VALIDITY;

D O I：

10.1007/s12070-025-05621-2

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

IntroductionLaryngopharyngeal reflux (LPR) is a common disease in the outpatient department of otolaryngology and is characterised by backflow of stomach contents into the pharynx and larynx resulting in significant negative impact on the quality of life of patients. The aim of study was to assess the effect of proton pump inhibitor (PPI) on quality of life in patients with LPR.Method110 patients diagnosed with LPR were enrolled in study and prescribed omeprazole (20 mg) twice daily for 12 weeks. The Reflux Symptom Index (RSI), Reflux Finding Score (RFS) and LPR-health-related quality of life (HRQOL) were recorded for each patient at the initial visit and at 4th, 8th and 12th week follow-up visits.ResultsMean RSI, RFS, HRQOL was 15.28 +/- 1.19, 12.65 +/- 1.16 and 77.77 +/- 11.80 respectively at baseline. Significant improvement was observed in RSI and RFS scores after treatment. The HRQOL score also showed gradual improvement after PPI treatment.ConclusionPPI treatment brought about a significant improvement in signs, symptoms and quality of life of LPR patients.

引用

页数：5

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