Application of rheology to hot melt extrusion: Theory and practice

被引：0
作者：
Wang, Yisen [1 ,2 ]
Li, Xianfu [1 ,2 ]
Shuai, Siyi [2 ]
Zhang, Hui [2 ]
Liu, Nan [2 ]
Wang, Zengming [2 ]
Jin, Lili [1 ]
Zheng, Aiping [2 ]
机构：
[1] Yanbian Univ, Coll Pharm, Yanji 133002, Peoples R China
[2] Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2025年 / 680卷
关键词：
Rheology; Hot melt extrusion; Polymer; Melt; AMORPHOUS SOLID DISPERSIONS; DRUG-POLYMER INTERACTIONS; METHYLCELLULOSE ACETATE SUCCINATE; THERMAL-DEGRADATION; RAMAN-SPECTROSCOPY; SLIT DIE; PHARMACEUTICAL EXCIPIENTS; VISCOELASTIC PROPERTIES; STATE CHARACTERIZATION; POLY(ETHYLENE OXIDE);
D O I：
10.1016/j.ijpharm.2025.125742
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hot melt extrusion (HME) has become a key manufacturing method in the pharmaceutical industry for developing novel drug delivery systems, due to its solvent-free nature, ease of operation, and ability to achieve onestep molding and continuous processing. The rheological properties of drug-polymer systems play a crucial role in determining the processability of formulations and the final product quality. This review systematically summarizes the shear-thinning and viscoelastic properties related to polymer melts, as well as the relevant rheological models. It aims to provide a theoretical basis for selecting excipients in HME formulations through the application of rheology and to guide the design of process parameters. Additionally, the review details the application of rheology in the scale-up and modeling of HME processes, exploring its potential for integration with continuous manufacturing, fused deposition modeling 3D printing, and machine learning, with the expectation of empowering HME drug development and playing a valuable role.
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页数：17
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