Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa

被引：1

作者：

Bellomo, Claudia ^{[1
]}

Furone, Francesca ^{[1
]}

Rotondo, Roberta ^{[2
]}

Ciscognetti, Ilaria ^{[1
]}

Carpinelli, Martina ^{[1
]}

Nicoletti, Martina ^{[1
]}

D'Aniello, Genoveffa ^{[3
]}

Sepe, Leandra ^{[4
]}

Barone, Maria Vittoria ^{[1
,3
]}

Nanayakkara, Merlin ^{[5
]}

机构：

[1] Univ Federico II, Dept Translat Med Sci, Sect Pediat, Via S Pansini 5, I-80131 Naples, Italy

[2] Univ Parma, Dept Med & Surg, I-43121 Parma, Italy

[3] Univ Federico II, ELFID European Lab Invest Food Induced Dis, Via S Pansini 5, I-80131 Naples, Italy

[4] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy

[5] Federico II Univ Hosp, I-80131 Naples, Italy

来源：

CELLS | 2024年 / 13卷 / 23期

关键词：

protein tyrosine phosphatases; celiac disease; diabetes; inflammatory bowel diseases; intestinal mucosa; KAPPA PTPRK GENE; GASTROINTESTINAL SYMPTOMS; IMMUNE-RESPONSE; TYPE-1; PTPN2; CELLS; RISK; SUSCEPTIBILITY; ASSOCIATION; MECHANISMS;

D O I：

10.3390/cells13231981

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous cellular processes, such as cell growth, inflammation, differentiation, immune-mediated responses and oncogenic transformation. The aim of this review is to review the literature concerning the role of several PTPs-PTPN22, PTPN2, PTPN6, PTPN11, PTP sigma, DUSP2, DUSP6 and PTPRK-at the level of the intestinal mucosa in inflammatory bowel disease (IBD), celiac disease (CeD) and type 1 diabetes (T1D) in both in vitro and in vivo models. The results revealed shared features, at the level of the intestinal mucosa, between these diseases characterized by alterations of different biological processes, such as proliferation, autoimmunity, cell death, autophagy and inflammation. PTPs are now actively studied to develop new drugs. Also considering the availability of organoids as models to test new drugs in personalized ways, it is very likely that soon these proteins will be the targets of useful drugs.

引用

页数：16

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