Disseminated opportunistic infections masquerading as central nervous system malignancies

被引：1

作者：

Tawfik, Ossama ^{[1
,2
]}

Hassan, Amira ^{[1
,2
]}

Mohamed, Wael ^{[3
]}

Essmyer, Cynthia ^{[1
,2
]}

Ewing, Eric ^{[1
,2
]}

Lem, Vincent ^{[3
]}

Grobelny, Bartosz ^{[4
]}

Breshears, Jonathan ^{[4
]}

Akhtar, Naveed ^{[5
]}

机构：

[1] St Lukes Hlth Syst Kansas City, Dept Pathol, Kansas City, MO USA

[2] MAWD Pathol Grp, Kansas City, KS USA

[3] St Lukes Hlth Syst Kansas City, Dept Internal Med, Kansas City, MO USA

[4] St Lukes Hlth Syst Kansas City, Dept Neurosurg, Kansas City, MO USA

[5] St Lukes Hlth Syst Kansas City, Dept Radiol, Kansas City, MO USA

来源：

HUMAN PATHOLOGY REPORTS | 2022年 / 28卷

关键词：

Toxoplasmosis; Nocardiosis; Encephalitis; Brain tumor; Immunocompromised; TOXOPLASMA-GONDII INFECTION; DISSEMINATED NOCARDIOSIS; UNITED-STATES; ENCEPHALITIS; THERAPY;

D O I：

10.1016/j.hpr.2022.300629

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Central nervous system manifestations are not only rare but extremely challenging to diagnose in patients with disseminated opportunistic infections. These CNS presentations can be very non-specific. On rare occasions, they can present as space-occupying lesions raising suspicions of primary or metastatic tumors. In this manuscript, we report a series of three cases of disseminated opportunistic infections with space-occupying lesions in the brains that are extremely challenging to diagnose. We are reporting a series of three cases of disseminated opportunistic infections with intracranial space-occupying lesions that were extremely challenging to diagnose; two patients with disseminated toxoplasmosis and one with disseminated nocardiosis. The clinicopathologic findings, radiological studies, and important diagnostic tests are discussed along with a review of the literature.

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