The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment

被引：1

作者：

Navarro-Diaz, Maruja ^{[1
,2
]}

Lopez-Martinez, Marina ^{[3
,4
]}

机构：

[1] Germans Trias & Pujols Res Insitute, Genom Platform, Badalona 08916, Spain

[2] St Joan Despi Moises Broggi Hosp, Nephrol Dept, St Joan Despi 08970, Spain

[3] Vall dHebron Univ Hosp, Dept Nephrol, Barcelona 08035, Spain

[4] Univ Autonoma Barcelona, Dept Med, Bellaterra 08193, Spain

来源：

BIOMEDICINES | 2025年 / 13卷 / 05期

关键词：

microRNA; biomarker; obesity-related glomerulopathy; GLUCOSE-METABOLISM; INSULIN-RESISTANCE; OVEREXPRESSION; NEPHROPATHY; KIDNEY; CANCER; RISK;

D O I：

10.3390/biomedicines13051030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity increases the risk of cardiovascular disease, diabetes and chronic kidney disease. Obesity-related glomerulopathy (ORG) is a potentially reversible cause of kidney disease that often progresses silently until it reaches irreversible stages. However, we are still lacking a sensitive and specific biomarker to identify patients with obesity who are at risk of developing CKD. The role of microRNAs (miRNAs) has emerged as a promising area for diagnostic and therapeutic applications in kidney disease. Recent research has highlighted the specific roles of various miRNAs in renal function, showing that their dysregulation can contribute to the development of kidney diseases. This review will discuss the emerging role of miRNAs in the context of ORG, focusing on their potential as biomarkers and therapeutic targets for this increasingly prevalent disease.

引用

页数：12

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