Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases

被引：0
作者：
Chen, Wan [1 ,3 ]
Li, Mei-Ling [1 ]
Zeng, Guang [1 ]
Xu, Xiang-Yu [1 ]
Yin, Shan-Hui [1 ]
Xu, Can [1 ]
Li, Linlin [3 ]
Wen, Kaikai [3 ]
Yu, Xiao-Hua [2 ]
Wang, Gang [1 ]
机构：
[1] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China
[2] Hainan Med Univ, Inst Clin Med, Affiliated Hosp 2, Haikou 570100, Hainan, Peoples R China
[3] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R China
来源：
PHARMACOLOGICAL RESEARCH | 2025年 / 217卷
基金：
中国国家自然科学基金;
关键词：
Cardiovascular diseases; Metabolic diseases; Gut microbiota; Gut microbiota-derived metabolite; Phenylacetylglutamine; ORGANIC ANION TRANSPORTERS; FATTY LIVER-DISEASE; PHENYLACETALDEHYDE DEHYDROGENASE; PHENYLALANINE DEHYDROGENASE; UREMIC TOXIN; HEALTH; ACID; TRANSPLANTATION; OBESITY; INFLAMMATION;
D O I：
10.1016/j.phrs.2025.107794
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aging of population coupled with unhealthy dietary habits among residents has led to a rise in the incidence of cardiovascular and metabolic diseases (CVMDs). Extensive research has highlighted the role of gut microbiotaderived metabolites in CVMDs. Among these metabolites, phenylacetylglutamine (PAGln), a meta-organismal prothrombotic metabolite, has been proved to promote the progression of CVMDs. This bacterial derived metabolite is a byproduct of amino acid comes from phenylalanine (Phe) in the diet. There are increasing evidence showing that the level of PAGln is associated with the risk of developing CVMDs. To provide a comprehensive understanding of the role of PAGln in CVMDs, this review delves into the production and metabolic pathways of PAGln and discusses the links of PAGln and the pathogenesis of CVMDs.
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页数：12
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