The Current Landscape of Molecular Pathology for the Diagnosis and Treatment of Pediatric Medulloblastoma

被引：0

作者：

Koch, Alayna ^{[1
]}

Childress, Ashley ^{[1
]}

Vallee, Emma ^{[1
]}

Steller, Alyssa ^{[1
]}

Raskin, Scott ^{[2
,3
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA

[2] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229 USA

[3] Cincinnati Childrens Hosp Med Ctr, Cure Starts Now Fdn Brain Tumor Ctr, Canc & Blood Dis Inst, Div Oncol, 3333 Burnet Ave,MLC 7018, Cincinnati, OH 45229 USA

来源：

JOURNAL OF MOLECULAR PATHOLOGY | 2025年 / 6卷 / 02期

关键词：

medulloblastoma (MB); molecular pathology; methylation profiling; wingless (WNT); sonic hedgehog (SHH); group; 3; 4; CLASSIFICATION;

D O I：

10.3390/jmp6020011

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Medulloblastoma (MB) is a malignant brain tumor that requires intense multimodal treatment. There is significant treatment-related morbidity associated with MB, and overall prognosis varies between the subgroups of the disease. These tumors were previously risk-stratified based solely on histopathological features. However, advancements in oncologic molecular research have led to novel changes to MB tumor classification, which also affects the prognosis and treatment strategies for individual patients. The WHO CNS5 now recognizes four main molecular subgroups of MB. Each subgroup contains its own genomic heterogeneity that correlates with a unique way to risk stratify patients, determine overall prognosis, and inform treatment. These discoveries have already impacted the implications and outcomes of current treatments based on the subgroup of patients. Ongoing research to better understand this classification system has paved the way for the development of molecular targeted therapy.

引用

页数：10

共 33 条

[1] Medulloblastoma: Molecular Classification-Based Personal Therapeutics [J].

Archer, Tenley C. ;

Mahoney, Elizabeth L. ;

Pomeroy, Scott L. .

NEUROTHERAPEUTICS, 2017, 14 (02) :265-273

[2]

Choi Jung Yoon, 2023, Brain Tumor Res Treat, V11, P28, DOI 10.14791/btrt.2022.0046

[3] Medulloblastoma: WHO 2021 and Beyond [J].

Cotter, Jennifer A. ;

Hawkins, Cynthia .

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 2022, 25 (01) :23-33

[4] Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables [J].

Ellison, David W. ;

Kocak, Mehmet ;

Dalton, James ;

Megahed, Hisham ;

Lusher, Meryl E. ;

Ryan, Sarra L. ;

Zhao, Wei ;

Nicholson, Sarah Leigh ;

Taylor, Roger E. ;

Bailey, Simon ;

Clifford, Steven C. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (11) :1400-1407

[5] Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03) [J].

Gajjar, Amar ;

Robinson, Giles W. ;

Smith, Kyle S. ;

Lin, Tong ;

Merchant, Thomas E. ;

Chintagumpala, Murali ;

Mahajan, Anita ;

Su, Jack ;

Bouffet, Eric ;

Bartels, Ute ;

Schechter, Tal ;

Hassall, Tim ;

Robertson, Thomas ;

Nicholls, Wayne ;

Gururangan, Sridharan ;

Schroeder, Kristin ;

Sullivan, Michael ;

Wheeler, Greg ;

Hansford, Jordan R. ;

Kellie, Stewart J. ;

McCowage, Geoffrey ;

Cohn, Richard ;

Fisher, Michael J. ;

Krasin, Matthew J. ;

Stewart, Clinton F. ;

Broniscer, Alberto ;

Buchhalter, Ivo ;

Tatevossian, Ruth G. ;

Orr, Brent A. ;

Neale, Geoff ;

Klimo, Paul ;

Boop, Frederick ;

Srinivasan, Ashok ;

Pfister, Stefan M. ;

Gilbertson, Richard J. ;

Onar-Thomas, Arzu ;

Ellison, David W. ;

Northcott, Paul A. .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (07) :822-+

[6] OUTCOMES OF SONIC HEDGEHOG (SHH) MEDULLOBLASTOMA (MB) IN CHILDREN AND ADULTS TREATED WITH RISK-ADAPTED THERAPY ON A PROSPECTIVE INTERNATIONAL PROTOCOL (SJMB12) [J].

Gajjar, Amar J. ;

Orr, Brent ;

Ellison, David ;

Lafay-Cousin, Lucie ;

Minturn, Jane ;

Fisher, Michael ;

Bendel, Anne ;

Hwang, Eugene ;

Murray, Jeffrey ;

Landi, Daniel ;

Smith, Amy ;

Gottardo, Nicholas ;

Valvi, Santhosh ;

Hassal, Tim ;

Elster, Jennifer ;

Perrault, Sebastian ;

Ramaswamy, Vijay ;

Partap, Sonia ;

Laughton, Stephen ;

Cohn, Richard ;

Chintagumpala, Murali ;

McCowage, Geoffrey ;

Hansford, Jordan ;

Sullivan, Michael ;

Sayour, Elias ;

Bowers, Daniel ;

Marks, Asher ;

Huang, Jie ;

Lucas, John ;

Tinkle, Christopher ;

Pinto, Soniya ;

Bag, Asim ;

Sabin, Noah ;

Northcott, Paul ;

Klimo, Paul ;

Merchant, Thomas E. ;

Onar-Thomas, Arzu ;

Robinson, Giles W. .

NEURO-ONCOLOGY, 2024, 26

[7] Molecular Targeted Therapies: Time for a Paradigm Shift in Medulloblastoma Treatment? [J].

Gatto, Lidia ;

Franceschi, Enrico ;

Tosoni, Alicia ;

Di Nunno, Vincenzo ;

Bartolini, Stefania ;

Brandes, Alba Ariela .

CANCERS, 2022, 14 (02)

[8] Development of Randomized Trials in Adults with Medulloblastoma-The Example of EORTC 1634-BTG/NOA-23 [J].

Hau, Peter ;

Frappaz, Didier ;

Hovey, Elizabeth ;

McCabe, Martin G. ;

Pajtler, Kristian W. ;

Wiestler, Benedikt ;

Seidel, Clemens ;

Combs, Stephanie E. ;

Dirven, Linda ;

Klein, Martin ;

Anazodo, Antoinette ;

Hattingen, Elke ;

Hofer, Silvia ;

Pfister, Stefan M. ;

Zimmer, Claus ;

Kortmann, Rolf-Dieter ;

Sunyach, Marie-Pierre ;

Tanguy, Ronan ;

Effeney, Rachel ;

von Deimling, Andreas ;

Sahm, Felix ;

Rutkowski, Stefan ;

Berghoff, Anna S. ;

Franceschi, Enrico ;

Pineda, Estela ;

Beier, Dagmar ;

Peeters, Ellen ;

Gorlia, Thierry ;

Vanlancker, Maureen ;

Bromberg, Jacoline E. C. ;

Gautier, Julien ;

Ziegler, David S. ;

Preusser, Matthias ;

Wick, Wolfgang ;

Weller, Michael .

CANCERS, 2021, 13 (14)

[9] Relapsed Medulloblastoma in Pre-Irradiated Patients: Current Practice for Diagnostics and Treatment [J].

Hill, Rebecca M. ;

Plasschaert, Sabine L. A. ;

Timmermann, Beate ;

Dufour, Christelle ;

Aquilina, Kristian ;

Avula, Shivaram ;

Donovan, Laura ;

Lequin, Maarten ;

Pietsch, Torsten ;

Thomale, Ulrich ;

Tippelt, Stephan ;

Wesseling, Pieter ;

Rutkowski, Stefan ;

Clifford, Steven C. ;

Pfister, Stefan M. ;

Bailey, Simon ;

Fleischhack, Gudrun .

CANCERS, 2022, 14 (01)

[10] Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies [J].

Holmberg, Karl O. ;

Borgenvik, Anna ;

Zhao, Miao ;

Giraud, Geraldine ;

Swartling, Fredrik J. .

CANCERS, 2024, 16 (09)

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