EmsB Microsatellite Analysis of Echinococcus multilocularis Specimens Isolated from Belgian Patients with Alveolar Echinococcosis and from Animal Hosts

被引：0

作者：

Egrek, Sabrina ^{[1
,2
]}

Knapp, Jenny ^{[3
,4
]}

Sacheli, Rosalie ^{[1
,2
]}

El Moussaoui, Khalid ^{[1
]}

Leonard, Philippe ^{[2
,5
]}

Larranaga Lapique, Eva ^{[6
]}

Millon, Laurence ^{[3
,4
]}

Engelskirchen, Sara ^{[7
]}

Detry, Olivier ^{[2
,8
]}

Linden, Annick ^{[2
,7
]}

Hayette, Marie-Pierre ^{[1
,2
]}

机构：

[1] Univ Hosp Liege, Ctr Interdisciplinary Res Med CIRM, Dept Clin Microbiol, Belgian Natl Reference Lab Echinococcosis, B-4000 Liege, Belgium

[2] Univ Hosp Liege CHU ULiege, EchinoLiege, Ave Hop 1, B-4000 Liege, Belgium

[3] Univ Marie & Louis Pasteur, Lab Chronoenvironm UMR CNRS 6249, F-25030 Besancon, France

[4] Univ Hosp Besancon, Natl Reference Ctr Echinococcoses, Dept Parasitol Mycol, F-25030 Besancon, France

[5] Univ Hosp Liege, Dept Infect & Trop Dis, B-4000 Liege, Belgium

[6] Univ Hosp Brussels, Dept Clin Infect Dis, B-1070 Brussels, Belgium

[7] Univ Liege, Fac Vet Med, Fundamental & Appl Res Anim & Hlth FARAH, B-4000 Liege, Belgium

[8] Univ Hosp Liege, Dept Abdominal Surg & Transplantat, B-4000 Liege, Belgium

来源：

PATHOGENS | 2025年 / 14卷 / 06期

关键词：

Echinococcus multilocularis; alveolar echinococcosis; human; animal hosts; Belgium; EmsB Microsatellite; FOXES VULPES-VULPES; PREVALENCE; LOCI;

D O I：

10.3390/pathogens14060584

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Alveolar echinococcosis (AE), caused by Echinococcus multilocularis (E. multilocularis), is a severe parasitic zoonosis that is potentially fatal for humans. The parasite is primarily transmitted by wildlife, with red foxes acting as definitive hosts and rodents as intermediate hosts, while humans can become accidental but dead-end hosts. The aim of this study is to use EmsB typing on E. multilocularis isolates from human AE cases and local animals such as foxes and rodents. In this study, retrospective EmsB typing was performed on 39 samples, including 11 tissue samples from 10 patients, 18 fecal swabs from foxes, and 10 tissue samples from rodents. A dendrogram was created to determine the EmsB profiles present. The results showed that all the rodent samples were associated with the EmsB P1 profile (10/10), while the human and fox samples shared the EmsB profile P1 (5/11 humans and 8/18 foxes), a profile near P4 (2/11 humans and 3 foxes), and a profile near P8 (1/11 humans and 1/18 foxes). The study demonstrates that the same EmsB profiles circulate among humans and animals, confirming that wildlife reservoirs play a key role in transmission.

引用

页数：16

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