Viral factors underlying the pandemic potential of influenza viruses

被引：0

作者：

Neumann, Gabriele ^{[1
]}

Eisfeld, Amie J. ^{[1
]}

Kawaoka, Yoshihiro ^{[1
,2
,3
,4
]}

机构：

[1] Univ Wisconsin Madison, Influenza Res Inst, Dept Pathobiol Sci, Madison, WI 53706 USA

[2] Univ Tokyo, Inst Med Sci, Dept Virol, Tokyo, Japan

[3] Univ Tokyo, Infect & Adv Res Ctr UTOPIA, Univ Tokyo Pandem Preparedness, Tokyo, Japan

[4] Natl Ctr Global Hlth & Med, Res Inst, Res Ctr Global Viral Dis, Tokyo, Japan

来源：

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | 2025年 / 89卷 / 02期

关键词：

influenza; highly pathogenic; H5; HA; PB2; NP; A H5N1 VIRUS; RESPIRATORY DROPLET TRANSMISSION; RECEPTOR-BINDING SPECIFICITY; TO-PERSON TRANSMISSION; FOWL PLAGUE VIRUS; AVIAN-INFLUENZA; MOLECULAR CHARACTERIZATION; HUMAN INFECTION; A(H10N7) VIRUS; AIRBORNE TRANSMISSION;

D O I：

10.1128/mmbr.00066-24

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Over the past 25 years, there has been an increasing number of mammalian (including human) infections caused by avian influenza A viruses that resulted in mild to severe illnesses. These viruses typically did not spread between mammals through aerosols in nature or in experimental settings. However, recently, this has changed, with several avian influenza A viruses exhibiting aerosol transmissibility among mammals, indicating that these viruses may pose a greater pandemic risk. In this review, we examine the current situation and discuss the mutations that may be necessary for avian influenza A viruses to efficiently replicate in mammals and transmit among them via aerosols.

引用

页数：20

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