Mps1 kinase functions in mitotic spindle assembly and error correction

被引：0

作者：

Bolanos-Garcia, Victor M. ^{[1
]}

机构：

[1] Oxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Oxford OX3 0BP, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2025年 / 50卷 / 05期

关键词：

KINETOCHORE-MICROTUBULE ATTACHMENT; TPR DOMAIN; CHECKPOINT; PROTEIN; COMPLEX; LOCALIZATION; REVEALS; PHOSPHORYLATION; INHIBITORS; BINDING;

D O I：

10.1016/j.tibs.2025.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein kinase Mps1 (also known as TTK) is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures accurate chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bioriented on the mitotic spindle. Mps1 kinase is an important upstream regulator of the SAC and its recruitment to kinetochores critical for initiating SAC signaling. This review discusses the current understanding of Mps1 essential functions in the SAC, the emerging details of Mps1 role in error correction to safeguard genome stability, and the therapeutic potential of Mps1 inhibition for the treatment of cancer types associated with aberrant SAC signaling and chromosome segregation defects.

引用

页码：438 / 453

页数：16

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