Toxicity Associated with Gold Nanoparticles: A Review

被引:0
作者
Chakravarthy K.K.J. [1 ]
Brahmanandam P.S. [2 ]
Uma G. [2 ]
Potukuchi D.M. [3 ]
Rao N.S.S. [5 ]
Kumar G.A. [4 ]
Alla A.R.K. [6 ]
机构
[1] Department of Physics, BV Raju College, Bhimavaram, Vishnupur
[2] Department of Physics, Shri Vishnu Engineering College for Women (A), Bhimavaram, Vishnupur
[3] School of Renewable Energy and Environment, JNT University, Kakinada
[4] Physics, Govt. Junior College, Tallarevu
[5] Department of Dental Materials, Vishnu Dental College, Bhimavaram, Vishnupur
关键词
gold nanoparticles; green synthesized gold nanoparticles; in vitro studies; in vivo; nanotechnology; toxicity;
D O I
10.5281/zenodo.12187283
中图分类号
学科分类号
摘要
Gold nanoparticles (AuNPs) are by far the most studied nanomaterials by the scientific fraternity, possibly due to their immense potential in medical applications. Nevertheless, there is a disparity of opinion that prevailed concerning the toxicity of AuNPs. This study, therefore, presents a systematic review concerning toxicity related to AuNPs with the help of recently published databases. The disparity is due to the fact that the adoption of various protocols in the assessment of toxicity over the years that led to divergent views about the actual safety of AuNPs. This paper has considered a few recent research works and their databases to assess the toxicity of AuNPs in vivo and in vitro. Further, this paper also discussed the possible approaches that could effectively minimize the lethal effects of AuNPs and elaborated on the future scope of this interesting and highly useful research. For time being, it is concluded here that nanomaterial safety data are scarce, and it is not even an exaggeration to say that that is even scarcer than reported. © (2024) Society for Biomaterials & Artificial Organs #20005824.
引用
收藏
页码:121 / 127
页数:6
相关论文
共 49 条
[1]  
Brahmanandam P. S., Chakravarthy K. K. J., Ramakrishnam Raju G., Rao N. S., Satyavani M., Naveen Kumar V., Alla Rama Krishna, Ganesh Kadiyala K, Vinay P, Rao Ch, Laxmi Narsaiah E, Satish L, Feasible Solutions and Role of Nanomaterials in Combating the COVID-19 Pandemic: A Preliminary Study, J Trends in Biomaterials and Artificial Organs, 34, pp. 44-51, (2020)
[2]  
Kus-Lioekiewicz M., Fickers P., Ben Tahar I., Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies and Regulations, International journal of molecular sciences, 22, 20, (2021)
[3]  
Sahu S. C., Hayes A. W., Toxicity of nanomaterials found in human environment: A literature review, Toxicology Research and Application, 1, pp. 1-13, (2017)
[4]  
Mohanta D., Patnaik S., Sood S., Das N., Carbon nanotubes: Evaluation of toxicity at biointerfaces, J Pharm Anal, 9, 5, pp. 293-300, (2019)
[5]  
van der Zande Meike, Junker Rudiger, Frank Walboomers X., Jansen John A., Carbon Nanotubes in Animal Models: A Systematic Review on Toxic Potential, Tissue Engineering Part B: Reviews, 17, 1, pp. 57-69, (2011)
[6]  
O'Neal D. P., Hirsch L. R., Halas N. J., Payne J. D., West J. L., Photothermal tumor ablation in mice using near infrared-absorbing nanoparticles, Cancer Lett, 209, pp. 171-176, (2004)
[7]  
Chen H., Kou X., Yang Z., Ni W., Wang J., Shape- and size-dependent refractive index sensitivity of gold nanoparticles, Langmuir, 24, pp. 5233-5237, (2008)
[8]  
Li S. L., Zhang T., Wang T., Li L., Wang C., Su Z., The facile synthesis of hollow Au nanoflowers for synergistic chemo-photothermal cancer therapy, Chem. Commun, 51, pp. 14338-14341, (2015)
[9]  
Xiao T. J., Huang D., Wang D., Meng T., Yang X., Au and Au-Based nanomaterials: synthesis and recent progress in electrochemical sensor applications, Talanta, 206, (2019)
[10]  
Hu X., Zhang Y., Ding T., Liu J., Zhao H., Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities, Front Bioengineering and Biotechnology, 8, 1, (2020)