Synthesis of Chiral Dispiro-indolinone-pyrrolidine-rhodanines Using (R)/(S)-1-(2,4-dimethoxyphenyl)ethylamine

被引：0

作者：

Degtiarev, Anton D. ^{[1
]}

Barashkin, Aleksandr A. ^{[1
]}

Grishin, Yuri K. ^{[1
]}

Roznyatovsky, Vitaly A. ^{[1
]}

Tafeenko, Viktor A. ^{[1
]}

Tarasenko, Elena A. ^{[1
]}

Beloglazkina, Elena K. ^{[1
]}

机构：

[1] MV Lomonosov Moscow State Univ, Dept Chem, Moscow 119991, Russia

来源：

CHEMISTRYSELECT | 2025年 / 10卷 / 25期

关键词：

1; 3-dipolar cycloaddition; Azomethine ylides; Chiral amines; Rhodanines; Spiro-compounds; STAPHYLOCOCCUS-AUREUS MRSA; BIOLOGICAL EVALUATION; DERIVATIVES BEARING; ASYMMETRIC CONSTRUCTION; RHODANINE-3-ACETIC ACID; METHICILLIN-RESISTANT; AZOMETHINE YLIDES; INHIBITORS; DESIGN; PIOGLITAZONE;

D O I：

10.1002/slct.202503393

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of (R) or (S)-1-(2,4-dimethoxyphenyl)ethylamines as starting compounds makes it possible to obtain the individual enantiomers of dispiro-indolinone-pyrrolidine-rhodanines with a yield of up to 53% based on a three-step synthesis through the formation of 5-arylidenrhodanines with a chiral substituent at N(3) atom, their subsequent 1,3-dipolar cycloaddition with azomethine ylide generated in situ from isatin and sarcosine and chromatographic separation of the resulting diastereomers.

引用

页数：7

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