Blocking IL-23 Signaling Mitigates Cigarette Smoke-Induced Murine Emphysema

被引：1

作者：

Tian, Xue ^{[1
,2
]}

Wang, Shaohua ^{[1
]}

Zhang, Chujie ^{[3
]}

Prakash, Y.S. ^{[4
,5
]}

Vassallo, Robert ^{[1
,5
]}

机构：

[1] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN

[2] Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai

[3] Department of Cardiology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an

[4] Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN

[5] Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, MN

来源：

Environmental Toxicology | 2024年 / 39卷 / 12期

基金：

美国国家卫生研究院;

关键词：

apoptosis; emphysema; IL-23; immunoinflammatory cell infiltration; oxidative stress;

D O I：

10.1002/tox.24405

中图分类号：

学科分类号：

摘要：

Inflammatory cell infiltration is a characteristic feature of COPD and correlates directly with the severity of the disease. Interleukin-23 (IL-23) is a pro-inflammatory cytokine that regulates Th-17 inflammation, which mediates many pathophysiological events in COPD. The primary goal of this study was to determine the role of IL-23 as a mediator of key pathologic processes in cigarette smoke-induced COPD. In this study, we report an increase in IL23 gene expression in the lung biopsies of COPD patients compared to controls and identified a positive correlation between IL23 gene expression and disease severity. In a cigarette smoke-induced murine emphysema model, the suppression of IL-23 with a monoclonal blocking antibody reduced the severity of cigarette smoke-induced murine emphysema. Mechanistically, the suppression of IL-23 was associated with a reduction in immune cell infiltration, oxidative stress injury, and apoptosis, suggesting a role for IL-23 as an essential immune mediator of the inflammatory processes in the pathogenesis of CS-induced emphysema. © 2024 Wiley Periodicals LLC.

引用

页码：5334 / 5346

页数：12

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