Nanoparticles for Photodynamic Therapy of Breast Cancer: A Review of Recent Studies

被引：1

作者：

Bartusik-Aebisher, Dorota ^{[1
]}

Przygorzewska, Agnieszka ^{[2
]}

Woznicki, Pawel ^{[3
]}

Aebisher, David ^{[4
]}

机构：

[1] Univ Rzeszow, Fac Med, Dept Biochem & Gen Chem, Coll Med, PL-35310 Rzeszow, Poland

[2] Univ Rzeszow, Fac Med, English Div Sci Club, Coll Med, PL-35310 Rzeszow, Poland

[3] Univ Rzeszow, Fac Med, Doctoral Sch, Coll Med, PL-35310 Rzeszow, Poland

[4] Univ Rzeszow, Fac Med, Dept Photomed & Phys Chem, Coll Med, PL-35310 Rzeszow, Poland

来源：

MOLECULES | 2025年 / 30卷 / 07期

关键词：

nanoparticles; photodynamic therapy; PDT; latest research; breast cancer; NEAR-INFRARED LIGHT; HYALURONIC-ACID; ALBUMIN; MITOCHONDRIA; DELIVERY; PHOTOSENSITIZERS; PENETRATION; METABOLISM; MECHANISMS; STRATEGIES;

D O I：

10.3390/molecules30071571

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photodynamic therapy (PDT) is a therapeutic method based on the interaction between light and a photosensitizer. Supported by nanoparticles, this method represents a promising interdisciplinary approach for the treatment of many diseases. This article reviews the latest 2024 developments in the design and applications of nanoparticles dedicated to stand-alone PDT of breast cancer. Strategies to improve therapeutic efficacy by enhancing reactive oxygen species (ROS) production, precise delivery of photosensitizers and their stabilization in the systemic circulation are discussed, among others. Results from preclinical studies indicate significant improvements in therapeutic efficacy, including inhibition of tumor growth, reduction in metastasis and improvement of the immune microenvironment. The potential of these technologies to expand PDT applications in medicine and the need for further clinical trials to confirm their safety and efficacy are highlighted.

引用

页数：18

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