Systemic Treatment of Locally Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma

被引：1

作者：

Vento, Joseph ^{[1
]}

Zhang, Tian ^{[1
]}

Kapur, Payal ^{[2
]}

Hammers, Hans ^{[1
]}

Brugarolas, James ^{[1
]}

Qin, Qian ^{[1
]}

机构：

[1] Univ Texas Southwestern, Dept Internal Med, Div Hematol & Oncol, Dallas, TX 75235 USA

[2] Univ Texas Southwestern, Dept Pathol, Dallas, TX 75235 USA

来源：

CANCERS | 2025年 / 17卷 / 09期

关键词：

non-clear cell renal cell carcinoma; papillary renal cell carcinoma; chromophobe renal cell carcinoma; unclassified renal cell carcinoma/renal cell carcinoma not further classified; translocation renal cell carcinoma; collecting duct renal cell carcinoma; renal medullary carcinoma; COLLECTING DUCT CARCINOMA; PHASE-II; OPEN-LABEL; GENOMIC ANALYSIS; CABOZANTINIB; SUNITINIB; MULTICENTER; NIVOLUMAB; EVEROLIMUS; 1ST-LINE;

D O I：

10.3390/cancers17091527

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-clear cell renal cell carcinoma (nccRCC) represents a heterogenous group of malignancies with varying degrees of clinical aggressiveness and response to different systemic therapies. As the characterization of subtypes of nccRCC continues to evolve, it is important to understand the evidence around systemic treatments used in advanced or metastatic stages of specific subtypes. Here, we review the literature on systemic therapies in nccRCC, with a focus on prospective trials that included patients with papillary renal cell carcinoma (RCC), chromophobe RCC, RCC not further classified/unclassified RCC, translocation RCC, collecting duct RCC, and renal medullary carcinoma. We also review emerging treatments for other molecularly defined subtypes of this disease.

引用

页数：21

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