Olfactory Identification as a Biomarker for Cognitive Impairment: Insights from Healthy Aging, Subjective Cognitive Decline, and Mild Cognitive Impairment

被引：0
作者：
Bouhaben, Jaime [1 ]
Delgado-Lima, Alice Helena [1 ]
Delgado-Losada, Maria Luisa [1 ]
机构：
[1] Univ Complutense Madrid, Fac Psychol, Cognit Proc & Speech Therapy Dept, Expt Psychol, Pozuelo De Alarcon 28223, Spain
来源：
EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION | 2024年 / 14卷 / 12期
关键词：
olfaction; neuroplasticity; aging; subjective cognitive decline; cognitive impairment; mild cognitive impairment; olfactory identification; biomarker; ODOR IDENTIFICATION; MEMORY COMPLAINTS; ALZHEIMERS-DISEASE; EPISODIC MEMORY; DEMENTIA; DYSFUNCTION; RISK; DEFICITS; AGE; IMPLEMENTATION;
D O I：
10.3390/ejihpe14120196
中图分类号：
B849 [应用心理学];
学科分类号：
040203 ;
摘要：
Introduction: This study aims to investigate the relationship between olfactory identification (OI) and cognitive impairment by examining OI abilities across various stages of cognitive deterioration. Methods: A total of 264 participants were divided into three groups based on cognitive status: cognitively healthy, subjective cognitive, and mild cognitive impairment. All participants were assessed using the Sniffin' Sticks Olfactory Identification test and a comprehensive neuropsychological test battery. Results: Our results highlight the main effects of age and cognitive status on OI scores. Regarding cognitive abilities, OI is associated with measures of short-term memory, long-term, working memory, and selective attention. Finally, logistic regression models showed that OI is a significant predictor for discriminating SCD from CH, MCI from CH, and MCI from SCD. Discussion: These findings suggest the addition of olfactory identification measures in neuropsychological assessments could improve the early detection of individuals at risk for cognitive impairment.
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页码：2978 / 3000
页数：23
相关论文
共 103 条
[1]   Olfactory Dysfunction Predicts Subsequent Dementia in Older US Adults [J].
Adams, Dara R. ;
Kern, David W. ;
Wroblewski, Kristen E. ;
McClintock, Martha K. ;
Dale, William ;
Pinto, Jayant M. .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2018, 66 (01) :140-144
[2]   Volumetric MRI Demonstrates Atrophy of the Olfactory Cortex in AD [J].
Al-Otaibi, Majed ;
Lessard-Beaudoin, Melissa ;
Castellano, Christian -Alexandre ;
Gris, Denis ;
Cunnane, Stephen C. ;
Graham, Rona K. .
CURRENT ALZHEIMER RESEARCH, 2020, 17 (10) :904-915
[3]   Episodic Memory of Odors Stratifies Alzheimer Biomarkers in Normal Elderly [J].
Albers, Alefiya Dhilla ;
Asafu-Adjei, Josephine ;
Delaney, Mary K. ;
Kelly, Kathleen E. ;
Gomez-Isla, Teresa ;
Blacker, Deborah ;
Johnson, Keith A. ;
Sperling, Reisa A. ;
Hyman, Bradley T. ;
Betensky, Rebecca A. ;
Hastings, Lloyd ;
Albers, Mark W. .
ANNALS OF NEUROLOGY, 2016, 80 (06) :846-857
[4]   The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].
Albert, Marilyn S. ;
DeKosky, Steven T. ;
Dickson, Dennis ;
Dubois, Bruno ;
Feldman, Howard H. ;
Fox, Nick C. ;
Gamst, Anthony ;
Holtzman, David M. ;
Jagust, William J. ;
Petersen, Ronald C. ;
Snyder, Peter J. ;
Carrillo, Maria C. ;
Thies, Bill ;
Phelps, Creighton H. .
ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279
[5]  
AlOtaibi M., 2023, Alzheimers Dement, V19, pe060723, DOI [10.1002/alz.060723, DOI 10.1002/ALZ.060723]
[6]   Awareness of olfactory deficits in healthy aging, amnestic mild cognitive impairment and Alzheimer's disease [J].
Bahar-Fuchs, Alex ;
Moss, Simon ;
Rowe, Christopher ;
Savage, Greg .
INTERNATIONAL PSYCHOGERIATRICS, 2011, 23 (07) :1097-1106
[7]   Can I Smell Gas (or Is It Lilac)? Olfactory Semantic Deficits in Mild Cognitive Impairment and Alzheimer's Disease [J].
Bahar-Fuchs, Alex ;
Moss, Simon ;
Rowe, Christopher ;
Savage, Greg .
CHEMOSENSORY PERCEPTION, 2010, 3 (02) :118-128
[8]   The role of olfactory dysfunction in mild cognitive impairment and Alzheimer's disease: A meta-analysis [J].
Bouhaben, Jaime ;
Delgado-Lima, Alice Helena ;
Delgado-Losada, Maria Luisa .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2024, 123
[9]   Short- versus long-term prediction of dementia among subjects with low and high educational levels [J].
Chary, Emilie ;
Amieva, Helene ;
Peres, Karine ;
Orgogozo, Jean-Marc ;
Dartigues, Jean-Francois ;
Jacqmin-Gadda, Helene .
ALZHEIMERS & DEMENTIA, 2013, 9 (05) :562-571
[10]   An Examination of Semantic Impairment in Amnestic MCI and AD: What Can We Learn From Verbal Fluency? [J].
Chasles, M-J ;
Tremblay, A. ;
Escudier, F. ;
Lajeunesse, A. ;
Benoit, S. ;
Langlois, R. ;
Joubert, S. ;
Rouleau, I .
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2020, 35 (01) :22-30
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