The utility of collagen VII topical gene therapy in the treatment of surgical defect after excision of recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma

被引：1

作者：

Wallace, Molly ^{[1
]}

Dasgupta, Rishob ^{[1
]}

Cravero, Karen ^{[1
]}

Yang, Henry ^{[1
]}

South, Andrew P. ^{[1
]}

Nikbakht, Neda ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19144 USA

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2025年 / 193卷 / 02期

关键词：

D O I：

10.1093/bjd/ljaf128

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

This case report describes the use of beremagene geperpavec (B-VEC), the first FDA-approved topical gene therapy for recessive dystrophic epidermolysis bullosa (RDEB), in the treatment of a large surgical defect following excision of a squamous cell carcinoma in a 55-year-old patient with RDEB. After wide local excision, the wound was treated with B-VEC, resulting in complete healing within 7 weeks, with no complications or recurrence at the 10-month follow-up. This novel approach highlights the potential of B-VEC to improve surgical outcomes and wound healing in patients with RDEB.

引用

页码：337 / 339

页数：3

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