Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

被引：0

作者：

Zhan, Ying ^{[1
]}

Zuo, Feng ^{[2
]}

Zhang, Zongpeng ^{[2
]}

Wu, Xiaodan ^{[2
]}

Dai, Yingxin ^{[2
]}

Jiao, Tingting ^{[2
]}

Shi, Qingxue ^{[2
]}

Wang, Zhiguo ^{[2
]}

Zhang, Guoxu ^{[2
]}

机构：

[1] Northeastern Univ, Coll Med & Biol Informat Engn, Shenyang, Peoples R China

[2] Gen Hosp Northern Theater Command, Dept Nucl Med, Shenyang, Peoples R China

来源：

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2025年 / 218期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; TAU; PATHOLOGY; RECOMMENDATIONS; RADIOSYNTHESIS; DEMENTIA;

D O I：

10.3791/67574

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by cognitive dysfunction, decline in daily living abilities, and behavioral changes, imposing a significant economic and social burden worldwide. One of the primary pathological hallmarks of AD is the accumulation of neurofibrillary tangles formed by hyperphosphorylated tau protein. Positron emission tomography/magnetic resonance imaging (PET/MRI) provides detailed structural and functional information along with specific protein distributions, making it an increasingly valuable tool for AD diagnosis and research. 18F-AV-1451 is a radiotracer specifically designed for tau protein detection in PET imaging of brain tissue. This study presents a detailed protocol for the radiosynthesis of 18F-AV-1451, patient preparation, PET/MRI image acquisition techniques, and its potential applications in AD evaluation. 18F-AV-1451 PET/MRI could aid neurologists in diagnosing AD, assessing disease severity, and gaining insights into its pathological mechanisms. In conclusion, this protocol provides a sensitive, comprehensive, and non-invasive approach for the evaluation of AD, offering valuable insights into disease progression and pathology.

引用

页数：15

共 48 条

[1] Conquering Alzheimer′s: a look at the therapies of the future [J].

Abbott, Alison .

NATURE, 2023, 616 (7955) :26-28

[2] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

Albert, Marilyn S. ;

DeKosky, Steven T. ;

Dickson, Dennis ;

Dubois, Bruno ;

Feldman, Howard H. ;

Fox, Nick C. ;

Gamst, Anthony ;

Holtzman, David M. ;

Jagust, William J. ;

Petersen, Ronald C. ;

Snyder, Peter J. ;

Carrillo, Maria C. ;

Thies, Bill ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279

[3] Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease [J].

Alcolea, Daniel ;

Martinez-Lage, Pablo ;

Sanchez-Juan, Pascual ;

Olazaran, Javier ;

Antunez, Carmen ;

Izagirre, Andrea ;

Ecay-Torres, Mirian ;

Estanga, Ainara ;

Clerigue, Montserrat ;

Concepcion Guisasola, Maria ;

Sanchez Ruiz, Domingo ;

Marin Munoz, Juan ;

Calero, Miguel ;

Blesa, Rafael ;

Clarimon, Jordi ;

Carmona-Iragui, Maria ;

Morenas-Rodriguez, Estrella ;

Rodriguez-Rodriguez, Eloy ;

Vazquez Higuera, Jose Luis ;

Fortea, Juan ;

Lleo, Alberto .

NEUROLOGY, 2015, 85 (07) :626-633

[4]

Bhatt J., 2019, World Alzheimer Report 2019 Attitudes to Dementia

[5] Alzheimer's disease [J].

Scheltens, Philip ;

De Strooper, Bart ;

Kivipelto, Miia ;

Holstege, Henne ;

Chetelat, Gael ;

Teunissen, Charlotte E. ;

Cummings, Jeffrey ;

van der Flier, Wiesje M. .

LANCET, 2021, 397 (10284) :1577-1590

[6] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[7] Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry [J].

Braak, Heiko ;

Alafuzoff, Irina ;

Arzberger, Thomas ;

Kretzschmar, Hans ;

Del Tredici, Kelly .

ACTA NEUROPATHOLOGICA, 2006, 112 (04) :389-404

[8] Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment [J].

Chandra, Avinash ;

Valkimadi, Polytimi-Eleni ;

Pagano, Gennaro ;

Cousins, Oliver ;

Dervenoulas, George ;

Politis, Marios .

HUMAN BRAIN MAPPING, 2019, 40 (18) :5424-5442

[9] Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808 [J].

Chien, David T. ;

Szardenings, A. Katrin ;

Bahri, Shadfar ;

Walsh, Joseph C. ;

Mu, Fanrong ;

Xia, Chunfang ;

Shankle, William R. ;

Lerner, Alan J. ;

Su, Min-Ying ;

Elizarova, Arkadij ;

Kolb, Hartmuth C. .

JOURNAL OF ALZHEIMERS DISEASE, 2014, 38 (01) :171-184

[10] Longitudinal brain atrophy and CSF biomarkers in early-onset Alzheimer's disease [J].

Contador, Jose ;

Perez-Millan, Agnes ;

Tort-Merino, Adria ;

Balasa, Mircea ;

Falgas, Neus ;

Olives, Jaume ;

Castellvi, Magdalena ;

Borrego-Ecija, Sergi ;

Bosch, Beatriz ;

Fernandez-Villullas, Guadalupe ;

Ramos-Campoy, Oscar ;

Antonell, Anna ;

Bargallo, Nuria ;

Sanchez-Valle, Raquel ;

Sala-Llonch, Roser ;

Llado, Albert .

NEUROIMAGE-CLINICAL, 2021, 32

← 1 2 3 4 5 →