Expression of YAP1 and TAZ in Melanoma-, Bronchial- and Breast Carcinoma Brain Metastasis: Primary vs. Relapsed Tumors

被引：0

作者：

Dicke, Jill ^{[1
,2
]}

Hero, Laura ^{[1
,2
]}

Kuhl, Saskia ^{[1
,2
]}

Goldbrunner, Roland ^{[1
,2
]}

Timmer, Marco ^{[1
,2
]}

机构：

[1] Univ Cologne, Fac Med, Ctr Neurosurg, Dept Gen Neurosurg,Lab Neurooncol & Expt Neurosurg, Cologne, Germany

[2] Univ Cologne, Univ Hosp, Cologne, Germany

来源：

ANTICANCER RESEARCH | 2025年 / 45卷 / 05期

关键词：

YAP1; TAZ; melanoma; bronchial carcinoma; breast cancer; brain metastasis;

D O I：

10.21873/anticanres.17560

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Brain metastases from the most common primary sites - lung carcinoma, breast carcinoma, and melanoma - are more frequent than primary brain tumors. YAP1/TAZ are regulators of tissue growth and epithelial- mesenchymal transition (EMT) within the hippo pathway. The aim of the study was the evaluation of the role of YAP1/TAZ in brain metastasis. Materials and Methods: Expression levels of YAP1 and TAZ were measured in samples of primary and relapsed brain metastases from patients with melanoma, breast carcinoma, and bronchial carcinoma using qPCR and western blot. Results: Expression of YAP1 and TAZ was highest in melanoma followed by bronchial carcinoma and lowest in breast carcinoma. For YAP1, expression in primary metastasis was higher than in relapsed metastasis. Conclusion: Because of the important role of YAP1/TAZ in EMT, targeting these genes could be a promising approach to reduce the risk of metastasis.

引用

页码：1807 / 1812

页数：6

共 13 条

[1] Hippo pathway effectors YAP, TAZ and TEAD are associated with EMT master regulators ZEB, Snail and with aggressive phenotype in phyllodes breast tumors [J].